Rabbit Anti-ITGA6 Recombinant Antibody (VS3-CJ792)
CAT#: VS3-CJ792
This product is a rabbit antibody that recognizes human, mouse, and rat ITGA6 (CD49f).
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Neuropil
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12696/39935_B_8_5.jpg
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Specifications
- Immunogen
- Recombinant protein
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse, Rat ITGA6 (CD49f)
- Species Reactivity
- Human, Mouse, Rat
- Applications
- WB, IHC
- Conjugate
- Unconjugated
Product Property
- Purification
- Protein A affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- 40% Glycerol, 1% BSA, TBS, pH7.4.
- Preservative
- 0.05% Sodium Azide
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been tested for use in Western Blot, Immunohistochemistry.
Target
- Alternative Names
- CD49fB, JEB6, VLA-6, ITGA6
- Gene ID
- 3655
- UniProt ID
- P23229
- Sequence Similarities
- Belongs to the integrin alpha chain family.
- Cellular Localization
- Cell membrane, Membrane
- Post Translation Modifications
- Isoforms containing segment A, but not segment B, are the major targets for PMA-induced phosphorylation. Phosphorylation occurs on 'Ser-1103' of isoform alpha-6X1X2A. Phosphorylation is not required for the induction of integrin alpha-6A/beta-1 high affinity but may reduce the affinity for ligand.
Undergoes PLAU-mediated cleavage at residues Arg-634-635-Arg in a time-dependent manner to produce processed integrin alpha-6 (alpha6p) (PubMed:11359780, PubMed:15023541, PubMed:17303120).
Production of alpha6p enhances prostate cancer cell invasion and migration (PubMed:17303120).
Palmitoylation by DHHC3 enhances stability and cell surface expression.
- Protein Refseq
- NP_000201.2; NP_001073286.1; NP_001303235.1
- Function
- Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets (By similarity).
Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (By similarity).
Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity).
ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778).
ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760).
ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464).
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "ITGA6"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0947CT | Recombinant Mouse anti-Human ITGA6 Monoclonal antibody (NQ 5G20) | FC, ICC, IF, IHC-Fr, IHC-P, IP | |
| VS3-QX608 | Mouse Anti-ITGA6 Recombinant Antibody (clone 129CT49.6.5) | WB, ICC, IHC, FC | Mouse IgG1 |
| VS3-CJ96 | Mouse Anti-ITGA6 Recombinant Antibody (VS3-CJ96) | WB, ELISA | Mouse IgG |
| VS3-CJ791 | Mouse Anti-ITGA6 Recombinant Antibody (clone ebioGoH3) | IF, FC | Mouse IgG2a, κ |
| VS4-WK255 | Rabbit Anti-ITGA6 Recombinant Antibody (clone 4G10) | ELISA, IF, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1557CQ | Recombinant Rat Anti-Itga6 Antibody (GoH3) | BL, IHC, CyTOF, FC | IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1875 | Hi-Affi™ Recombinant Rabbit Anti-ITGA6 Monoclonal Antibody (DS1875AB) | WB, IHC | IgG |
| MOR-4628 | Hi-Affi™ Recombinant Rabbit Anti-ITGA6 Monoclonal Antibody (TH141DS) | WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC49 | Mouse Anti-ITGA6 Recombinant Antibody (VS-0924-YC49) - Cancer Stem Cell Marker | IHC | Mouse IgG1 |
| VS-0924-YC50 | Rabbit Anti-ITGA6 Antibody (VS-0924-YC50) - Cancer Stem Cell Marker | IHC, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3630 | Anti-ITGA6 Immunohistochemistry Kit | IHC | |
| VS-0525-XY3631 | Anti-Mouse ITGA6 Immunohistochemistry Kit | IHC | |
| VS-0525-XY3632 | Anti-Rat ITGA6 Immunohistochemistry Kit | IHC |
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