Mouse Anti-ITGA6 Recombinant Antibody (VS3-FY2746) (CAT#: VS3-FY2746)

• Host Species
• Mouse

• Type
• Mouse IgG

• Specificity
• Integrin subunit alpha 6 of human and mouse origins

• Species Reactivity
• Human, Mouse

• Applications
• WB, IHC, ICC, FC

• Conjugate
• Unconjugated, FITC

• MW
• The molecular weight of the target protein is approximately 126.6 kDa.

• Related Disease
• Epidermolysis Bullosa, Junctional 6, With Pyloric Atresia and Epidermolysis Bullosa, Junctional 5B, With Pyloric Atresia

• Clonality
• Monoclonal Antibody

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/2000
  Immunohistochemistry: 1/50-1/200
  Immunocytochemistry: 1/10-1/50
  Flow cytometry: 1/10-1/50

• Alternative Names
• Integrin Subunit Alpha 6

• Gene ID
• 3655

• UniProt ID
• P23229

• Sequence Similarities
• Belongs to the integrin alpha chain family.

• Cellular Localization
• Cell membrane

• Post Translation Modifications
• Isoforms containing segment A, but not segment B, are the major targets for PMA-induced phosphorylation.
  Phosphorylation occurs on 'Ser-1103' of isoform alpha-6X1X2A.
  Phosphorylation is not required for the induction of integrin alpha-6A/beta-1 high affinity but may reduce the affinity for ligand.
  Undergoes PLAU-mediated cleavage at residues Arg-634-635-Arg in a time-dependent manner to produce processed integrin alpha-6 (alpha6p).
  Production of alpha6p enhances prostate cancer cell invasion and migration.
  Palmitoylation by DHHC3 enhances stability and cell surface expression.
  Glycosylation at Asn78, Asn323, Asn223, Asn409, Asn770, Asn787, Asn930, Asn966, and Asn997
  Modification sites at PhosphoSitePlus
  Glycosylation from Gly
  Glycosylation from GlyGen 14 sites, 20 N-linked glycans (4 sites), 1 O-linked glycan (1 site)

• Protein Refseq
• XP_016859494.1; XP_016859495.1; XP_047300177.1; XP_047300178.1; XP_054197849.1

• Function
• Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets (By similarity).
  Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (By similarity).
  Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity).

Secondary Antibody

• 2ND-040CQ
• Goat Anti-Mouse IgG (H&L) Antibody

Isotype Control

• MRO-A1591-YJ
• Mouse IgG Isotype control, Polyclonal

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