Mouse Anti-ITGA6 Recombinant Antibody (VS3-FY2746)
CAT#: VS3-FY2746
The anti-ITGA6 antibody is a mouse recombinant monoclonal antibody, which has been intricately crafted to target the ITA6 protein, a calculated weight of 126.6 kDa. It shows capability of cross-reacting with human and mouse. The monoclonal antibody can be used in the area of Epidermolysis Bullosa, Junctional 6, with Pyloric Atresia and Epidermolysis Bullosa, Junctional 5B, With Pyloric Atresia. This monoclonal antibody can be used in Western Blot, Immunohistochemistry, Immunocytochemistry, Flow cytometry.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Neuropil
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12696/39935_B_8_5.jpg
Normal Tissue
Figure 2 Colon
Glandular cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12696/39935_A_9_3.jpg
Normal Tissue
Figure 3 Kidney
Proximal tubules (cell body)
Staining:Medium
Intensity: Moderate
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12696/39935_A_9_5.jpg
Normal Tissue
Figure 4 Testis
Preleptotene spermatocytes
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Spermatogonia cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12696/39935_A_4_6.jpg
Normal Tissue
Figure 5 Placenta
Trophoblastic cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12696/39935_A_3_7.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (BJ, HaCaT, HBEC3-KT, hTCEpi, hTERT-HME1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000091409-ITGA6
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Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Integrin subunit alpha 6 of human and mouse origins
- Species Reactivity
- Human, Mouse
- Applications
- WB, IHC, ICC, FC
- Conjugate
- Unconjugated, FITC
- MW
- The molecular weight of the target protein is approximately 126.6 kDa.
- Related Disease
- Epidermolysis Bullosa, Junctional 6, With Pyloric Atresia and Epidermolysis Bullosa, Junctional 5B, With Pyloric Atresia
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/2000
Immunohistochemistry: 1/50-1/200
Immunocytochemistry: 1/10-1/50
Flow cytometry: 1/10-1/50
Target
- Alternative Names
- Integrin Subunit Alpha 6
- Gene ID
- 3655
- UniProt ID
- P23229
- Sequence Similarities
- Belongs to the integrin alpha chain family.
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Isoforms containing segment A, but not segment B, are the major targets for PMA-induced phosphorylation.
Phosphorylation occurs on 'Ser-1103' of isoform alpha-6X1X2A.
Phosphorylation is not required for the induction of integrin alpha-6A/beta-1 high affinity but may reduce the affinity for ligand.
Undergoes PLAU-mediated cleavage at residues Arg-634-635-Arg in a time-dependent manner to produce processed integrin alpha-6 (alpha6p).
Production of alpha6p enhances prostate cancer cell invasion and migration.
Palmitoylation by DHHC3 enhances stability and cell surface expression.
Glycosylation at Asn78, Asn323, Asn223, Asn409, Asn770, Asn787, Asn930, Asn966, and Asn997
Modification sites at PhosphoSitePlus
Glycosylation from Gly
Glycosylation from GlyGen 14 sites, 20 N-linked glycans (4 sites), 1 O-linked glycan (1 site)
- Protein Refseq
- XP_016859494.1; XP_016859495.1; XP_047300177.1; XP_047300178.1; XP_054197849.1
- Function
- Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets (By similarity).
Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (By similarity).
Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "ITGA6"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1557CQ | Recombinant Rat Anti-Itga6 Antibody (GoH3) | BL, IHC, CyTOF, FC | IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1875 | Hi-Affi™ Recombinant Rabbit Anti-ITGA6 Monoclonal Antibody (DS1875AB) | WB, IHC | IgG |
| MOR-4628 | Hi-Affi™ Recombinant Rabbit Anti-ITGA6 Monoclonal Antibody (TH141DS) | WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-0850-CN | Recombinant Rabbit Anti-ITGA6 Monoclonal Antibody (CBACN-311) | WB, IHC | Rabbit IgG |
| ZG-1064F | Rat Anti-ITGA6 Antibody (clone NKI-GoH3) | FC, IHC-Fr, IP, ICC | Rat IgG2a |
| VS3-QX608 | Mouse Anti-ITGA6 Recombinant Antibody (clone 129CT49.6.5) | WB, ICC, IHC, FC | Mouse IgG1 |
| VS3-CJ96 | Mouse Anti-ITGA6 Recombinant Antibody (VS3-CJ96) | WB, ELISA | Mouse IgG |
| VS3-CJ791 | Mouse Anti-ITGA6 Recombinant Antibody (clone ebioGoH3) | IF, FC | Mouse IgG2a, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC49 | Mouse Anti-ITGA6 Recombinant Antibody (VS-0924-YC49) - Cancer Stem Cell Marker | IHC | Mouse IgG1 |
| VS-0924-YC50 | Rabbit Anti-ITGA6 Antibody (VS-0924-YC50) - Cancer Stem Cell Marker | IHC, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3630 | Anti-ITGA6 Immunohistochemistry Kit | IHC | |
| VS-0525-XY3631 | Anti-Mouse ITGA6 Immunohistochemistry Kit | IHC | |
| VS-0525-XY3632 | Anti-Rat ITGA6 Immunohistochemistry Kit | IHC |
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