Anti-ITGAX (clone W24V51) Recombinant Antibody Coupled Liposome (VS-1024-FY55) (CAT#: VS-1024-FY55)

• Potential Clinical Applications
• This immunoliposome has the potential to inhibit tumor growth and prolong overall survival.

• Immunoliposomes Method
• The liposome solution was introduced to a mixture of 2-IT and anti-CD11c monoclonal antibody, maintaining a molar ratio of 100:1, and the suspension was stirred for 1 hour. Subsequently, the suspension was purified using an AKTA Prime protein purifier in combination with a Sepharose CL-4B gel column to eliminate unencapsulated OVA and any un-crosslinked CD11c monoclonal antibodies, resulting in the formation of LC-targeting immunoliposomes. As a control, immunoliposomes conjugated with CD19 monoclonal antibodies were also prepared.

• Clone
• W24V51

• Antibody Type
• IgG2a

• Antibody Host
• Rat

• Antibody Reactivity
• Mouse

• Antibody Description
• This antibody is a rat anti-mouse CD11c, classified as IgG2a isotype. The immunogen derives from dendritic cells isolated from C57BL/6 mice. It is suitable for use in flow cytometry (FCM) and immunoprecipitation (IP) assays.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• ITGAX

• Introduction
• This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. Two transcript variants encoding different isoforms have been found for this gene.

• Alternative Names
• Integrin Subunit Alpha X

• Full Name
• Integrin Subunit Alpha X

• Gene ID
• 3687

• UniProt ID
• P20702

• Cellular Localization
• Membrane

• Post Translation Modifications
• Glycosylation at Asn61, Asn89, Asn392, Asn697, Asn735, Asn899, Asn904, Asn939, and Asn1050 (NX_P20702 [NX_P20702-1])
  Modification sites at PhosphoSitePlus (P20702)
  Glycosylation from GlyConnect ITAX_HUMAN (1413)
  Glycosylation from GlyGen (P20702) 8 sites, 2 N-linked glycans (3 sites)

• Protein Refseq
• XP_011544154.1; XP_011544156.1

• Function
• Integrin alpha-X/beta-2 is a receptor for fibrinogen.
  It recognizes the sequence G-P-R in fibrinogen.
  It mediates cell-cell interaction during inflammatory responses.
  It is especially important in monocyte adhesion and chemotaxis.

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