ITGAX

ITGAX encodes the alpha subunit of the integrin receptor complex, which is involved in immune cell adhesion, migration, and signaling. This integrin is expressed predominantly on macrophages, dendritic cells, and neutrophils. ITGAX plays an important role in immune responses, especially in the context of inflammation, infection, and autoimmunity. It contributes to antigen presentation and the activation of T-cells. Mutations in ITGAX are associated with defects in immune responses and may contribute to autoimmune diseases such as rheumatoid arthritis.