Rabbit Anti-ITPR2 Recombinant Antibody (clone 2506W08)
CAT#: VS-0625-FY36
The Rabbit IgG monoclonal antibody, clone 2506W08, provides broad reactivity with ITPR2 in Human, Mouse, and Rat. Its immunogen is a recombinant Rat ITPR2 fusion protein, with an epitope spanning amino acids 1-641. With an approximate antigen size of 45 kDa, this antibody is applicable in IHC-Fr, Western Blot, IHC-P, and Dot Blot, offering versatile detection capabilities for ITPR2.
Gene Expression
Normal Tissue
Figure 5 Liver
Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/59144/134577_A_7_4.jpg
Normal Tissue
Figure 6 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/59144/134577_A_9_5.jpg
Normal Tissue
Figure 7 Testis
Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/59144/134577_A_5_6.jpg
Normal Tissue
Figure 8 Breast
Adipocytes Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/59144/134577_B_2_4.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced (TIME)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000123104-ITPR2
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & endoplasmic reticulum.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/62260/1408_C11_3_selected.jpg
Normal Tissue
Figure 2 IHC staining of human parathyroid gland
Immunohistochemical staining of human parathyroid gland shows cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/59144/134577_A_3_8_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/59144/134577_B_7_5.jpg
Normal Tissue
Figure 4 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/59144/134577_A_8_3.jpg
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Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Species Reactivity
- Human, Mouse, Rat
- Clone
- 2506W08
- Applications
- Immunohistochemistry-Frozen, Western Blot, Immunohistochemistry-Paraffin, Dot Blot
- Related Disease
- Anhidrosis, Isolated, With Normal Sweat Glands and Anhidrosis
Product Property
- Purification
- Purified with Protein A or G affinity chromatography
- Purity
- >90% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- 59% PBS, 40% glycerol (glycerin, glycerine), 0.05% BSA, pH 7.2-7.4
- Preservative
- 0.01% Sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Optimal dilutions for assays should be determined by the user.
Target
- Alternative Names
- Inositol 1,4,5-Trisphosphate Receptor Type 2
- Gene ID
- 3709
- UniProt ID
- Q14571
- Long Name
- Inositol 1,4,5-Trisphosphate Receptor Type 2
- Sequence Similarities
- Belongs to the InsP3 receptor family.
- Cellular Localization
- Endoplasmic reticulum membrane; Multi-pass membrane protein {ECO:0000250 UniProtKB:Q9Z329 | ECO:0000255}
Cytoplasmic vesicle, secretory vesicle membrane
- Post Translation Modifications
- Phosphorylation by cAMP-dependent PKA on Ser-937 increases calcium release.
Phosphorylation by CaMK2 on Ser-150 significantly decreases the channel open probability.
Ubiquitination at Lys909 and Lys1589
Modification sites at PhosphoSitePlus
Glycosylation
- Protein Refseq
- XP_016874755.1; XP_016874758.1; XP_047284757.1; XP_054227945.1; XP_054227946.1
- Function
- Inositol 1,4,5-trisphosphate-gated calcium channel that upon inositol 1,4,5-trisphosphate binding transports calcium from the endoplasmic reticulum lumen to cytoplasm.
Exists in two states; a long-lived closed state where the channel is essentially 'parked' with only very rare visits to an open state and that ligands facilitate the transition from the 'parked' state into a 'drive' mode represented by periods of bursting activity (By similarity).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "ITPR2"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-1984-CN | Rabbit Anti-ITPR2 Polyclonal Antibody (MRO-1984-CN) | Dot, IF, IHC, FC | Rabbit IgG |
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