Rabbit Anti-ITPR2 Recombinant Antibody (clone 2506W08) (CAT#: VS-0625-FY36)

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Species Reactivity
• Human, Mouse, Rat

• Clone
• 2506W08

• Applications
• Immunohistochemistry-Frozen, Western Blot, Immunohistochemistry-Paraffin, Dot Blot

• Related Disease
• Anhidrosis, Isolated, With Normal Sweat Glands and Anhidrosis

• Purification
• Purified with Protein A or G affinity chromatography

• Purity
• >90% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Buffer
• 59% PBS, 40% glycerol (glycerin, glycerine), 0.05% BSA, pH 7.2-7.4

• Preservative
• 0.01% Sodium azide

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• Optimal dilutions for assays should be determined by the user.

• Alternative Names
• Inositol 1,4,5-Trisphosphate Receptor Type 2

• Gene ID
• 3709

• UniProt ID
• Q14571

• Long Name
• Inositol 1,4,5-Trisphosphate Receptor Type 2

• Sequence Similarities
• Belongs to the InsP3 receptor family.

• Cellular Localization
• Endoplasmic reticulum membrane; Multi-pass membrane protein {ECO:0000250 UniProtKB:Q9Z329 | ECO:0000255}
  Cytoplasmic vesicle, secretory vesicle membrane

• Post Translation Modifications
• Phosphorylation by cAMP-dependent PKA on Ser-937 increases calcium release.
  Phosphorylation by CaMK2 on Ser-150 significantly decreases the channel open probability.
  Ubiquitination at Lys909 and Lys1589
  Modification sites at PhosphoSitePlus
  Glycosylation

• Protein Refseq
• XP_016874755.1; XP_016874758.1; XP_047284757.1; XP_054227945.1; XP_054227946.1

• Function
• Inositol 1,4,5-trisphosphate-gated calcium channel that upon inositol 1,4,5-trisphosphate binding transports calcium from the endoplasmic reticulum lumen to cytoplasm.
  Exists in two states; a long-lived closed state where the channel is essentially 'parked' with only very rare visits to an open state and that ligands facilitate the transition from the 'parked' state into a 'drive' mode represented by periods of bursting activity (By similarity).

Secondary Antibody

• 2ND-054CQ
• Goat Anti-Rabbit IgG Antibody, R-PE

• 2ND-055CQ
• Chicken Anti-Rabbit IgG (H&L) Antibody

• 2ND-057CQ
• Donkey Anti-Rabbit IgG (H&L) Antibody

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

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