CytoStream™ Rabbit Anti-KDM4B Recombinant Antibody (VS13-YC616) (CAT#: VS13-YC616)
The CytoStream™ Rabbit Anti-KDM4B Recombinant Antibody is specific for human, mouse and rat KDM4B. KDM4B, a histone demethylase specific for H3 Lys-9, plays a role in histone code regulation, demethylating trimethylated residues to generate formaldehyde and succinate. The anti-KDM4B antibody was developed and selected by our CytoStream™ platform and the mAb is recommended for use in flow cytometry staining (1/50-1/100).
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We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
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Subcellular Location and Protein Expression
RNA Expression
Figure 1 IF staining of human cell line SiHa
(Immunofluorescent staining of human cell line SiHa shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/71568/1923_A10_32_selected.jpg
(Immunofluorescent staining of human cell line SiHa shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/71568/1923_A10_32_selected.jpg
Figure 2 IF staining of human cell line HEK 293
(Immunofluorescent staining of human cell line HEK 293 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/71568/2031_A2_1_red_green.jpg
(Immunofluorescent staining of human cell line HEK 293 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/71568/2031_A2_1_red_green.jpg
Figure 3 RNA cell line category: Cell line enhanced (T-47d)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000127663-KDM4B
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000127663-KDM4B
Specifications
- Immunogen
- Recombinant human KDM4B.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat KDM4B
- Species Reactivity
- Human, Mouse, Rat
- Applications
- WB, IHC-P, ICC, IF, FC
- Conjugate
- NONE
- Related Disease
- Intellectual Developmental Disorder, Autosomal Dominant and Non-Specific Syndromic Intellectual Disability
Product Property
- Clonality
- Monoclonal
- Purification
- Affinity Chromatography purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS (pH 7.4) containing 150 mM NaCl and 50% Glycerol.
- Preservative
- 0.02% Sodium azide
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Western blot (WB): 1/500-1/1000
Immunohistochemistry (IHC): 1/50-1/100
Immunofluorescence (IF): 1/50-1/200
Flow cytometry (FC): 1/50-1/100
Target
- Alternative Names
- Lysine Demethylase 4B; JmjC Domain-Containing Histone Demethylation Protein 3B; Jumonji Domain-Containing Protein 2B; Lysine (K)-Specific Demethylase 4B; Jumonji Domain Containing 2B; Tudor Domain Containing 14B; JMJD2B;
- Gene ID
- 23030
- UniProt ID
- O94953
- Long Name
- Lysine Demethylase 4B
- Sequence Similarities
- Belongs to the JHDM3 histone demethylase family.
- Cellular Localization
- Nucleus
- Protein Refseq
- XP_005259578.2; XP_011526116.1; XP_011526119.1; XP_011526121.1; XP_011526122.1
- Function
- Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate.
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IgG Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| DrMAB-376 | Recombinant Human Anti-Human KDM4B Antibody, clone D437 | ELISA, IP-MS | IgG |
| VS3-FY1756 | Rabbit Anti-KDM4B Recombinant Antibody (clone R08-9G9) | WB, IHC-Fr, IHC-P, IF | Rabbit IgG |
| VS7-0425-WR202 | Mouse Anti-KDM4B Recombinant Antibody (clone 3A6H6) | FC | Mouse IgG1 |
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