CytoStream™ Rabbit Anti-KDM4B Recombinant Antibody (VS13-YC616) (CAT#: VS13-YC616)
The CytoStream™ Rabbit Anti-KDM4B Recombinant Antibody is specific for human, mouse and rat KDM4B. KDM4B, a histone demethylase specific for H3 Lys-9, plays a role in histone code regulation, demethylating trimethylated residues to generate formaldehyde and succinate. The anti-KDM4B antibody was developed and selected by our CytoStream™ platform and the mAb is recommended for use in flow cytometry staining (1/50-1/100).
Specific Inquiry
Subcellular Location and Protein Expression
RNA Expression
Figure 1 IF staining of human cell line SiHa
(Immunofluorescent staining of human cell line SiHa shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/71568/1923_A10_32_selected.jpg
(Immunofluorescent staining of human cell line SiHa shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/71568/1923_A10_32_selected.jpg
Figure 2 IF staining of human cell line HEK 293
(Immunofluorescent staining of human cell line HEK 293 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/71568/2031_A2_1_red_green.jpg
(Immunofluorescent staining of human cell line HEK 293 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/71568/2031_A2_1_red_green.jpg
Figure 3 RNA cell line category: Cell line enhanced (T-47d)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000127663-KDM4B
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000127663-KDM4B
Specifications
- Immunogen
- Recombinant human KDM4B.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat KDM4B
- Species Reactivity
- Human, Mouse, Rat
- Applications
- WB, IHC-P, ICC, IF, FC
- Conjugate
- NONE
- Related Disease
- Intellectual Developmental Disorder, Autosomal Dominant and Non-Specific Syndromic Intellectual Disability
Product Property
- Clonality
- Monoclonal
- Purification
- Affinity Chromatography purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS (pH 7.4) containing 150 mM NaCl and 50% Glycerol.
- Preservative
- 0.02% Sodium azide
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Western blot (WB): 1/500-1/1000
Immunohistochemistry (IHC): 1/50-1/100
Immunofluorescence (IF): 1/50-1/200
Flow cytometry (FC): 1/50-1/100
Target
- Alternative Names
- Lysine Demethylase 4B; JmjC Domain-Containing Histone Demethylation Protein 3B; Jumonji Domain-Containing Protein 2B; Lysine (K)-Specific Demethylase 4B; Jumonji Domain Containing 2B; Tudor Domain Containing 14B; JMJD2B;
- Gene ID
- 23030
- UniProt ID
- O94953
- Long Name
- Lysine Demethylase 4B
- Sequence Similarities
- Belongs to the JHDM3 histone demethylase family.
- Cellular Localization
- Nucleus
- Protein Refseq
- XP_005259578.2; XP_011526116.1; XP_011526119.1; XP_011526121.1; XP_011526122.1
- Function
- Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate.
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IgG Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| DrMAB-376 | Recombinant Human Anti-Human KDM4B Antibody, clone D437 | ELISA, IP-MS | IgG |
| VS3-FY1756 | Rabbit Anti-KDM4B Recombinant Antibody (clone R08-9G9) | WB, IHC-Fr, IHC-P, IF | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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