Mouse Anti-KIF11 Recombinant Antibody (VS3-FY2750) (CAT#: VS3-FY2750)

• Host Species
• Mouse

• Type
• Mouse IgG

• Specificity
• Kinesin family member 11 of human

• Species Reactivity
• Human

• Applications
• WB, IHC, FC, ELISA

• Conjugate
• Unconjugated, FITC

• MW
• The molecular weight of the target protein is approximately 119 kDa.

• Related Disease
• Microcephaly With Or Without Chorioretinopathy, Lymphedema, Or Impaired Intellectual Development and Microcephaly And Chorioretinopathy, Autosomal Recessive, 1

• Clonality
• Monoclonal Antibody

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/2000
  Immunohistochemistry: 1/50-1/200
  Flow cytometry: 1/50-1/200
  ELISA: 1/1000-1/10000

• Alternative Names
• Kinesin Family Member 11; Thyroid Receptor-Interacting Protein 5; Kinesin-Like Spindle Protein HKSP; Kinesin-Related Motor Protein Eg5; TR-Interacting Protein 5; Kinesin-Like Protein 1; TRIP-5; KNSL1

• Gene ID
• 3832

• Sequence Similarities
• Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. BimC subfamily.

• Cellular Localization
• Cytoplasm, cytoskeleton, spindle pole

• Post Translation Modifications
• Phosphorylated exclusively on serine during S phase, but on both serine and Thr-926 during mitosis, so controlling the association of KIF11 with the spindle apparatus.
  A subset of this protein primarily localized at the spindle pole is phosphorylated by NEK6 during mitosis; phosphorylation is required for mitotic function.
  Ubiquitinated at Lys-1034 by UHRF1 via 'Lys-63'-linked ubiquitin chains, leading to interaction with spindle assembly factor TPX2, thereby ensuring accurate distribution to the spindles during metaphase.
  Ubiquitination at Lys1034
  Modification sites at PhosphoSitePlus
  Glycosylation from GlyGen 1 site, 1 O-linked glycan (1 site)

• Protein Refseq
• NP_004514.2

• Function
• Motor protein required for establishing a bipolar spindle and thus contributing to chromosome congression during mitosis (PubMed:19001501, 37728657).
  Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface

Secondary Antibody

• 2ND-040CQ
• Goat Anti-Mouse IgG (H&L) Antibody

Isotype Control

• MRO-A1591-YJ
• Mouse IgG Isotype control, Polyclonal

Select a product category from the dropdown menu below to view related products.