Recombinant monoclonal antibody specially binds to keratin 17 (KRT17). This human anti-KRT17 antibody (A4) can be widely used in treatment of patients with epidermal proliferative dermatoses, especially psoriasis.
Figure 1 Western blot analysis using proteins from human gastric adenocarcinoma tissues shows KRT17 protein expression in tumor samples of various stages.
Knockdown of KRT17 mRNA and protein expression in gastric adenocarcinoma cell lines.
Chivu-Economescu, M., Dragu, D. L., Necula, L. G., Matei, L., Enciu, A. M., Bleotu, C., & Diaconu, C. C. (2017). Knockdown of KRT17 by siRNA induces antitumoral effects on gastric cancer cells. Gastric Cancer, 20(6), 948-959.
Figure 2 Downregulation of KRT17 inhibits cancer cell proliferation on AGS and NCI-N87 cell lines.
Cell proliferation was determined using CellTiter96 assay and recording absorbance at 550 nm with a spectrophotometric plate reader.
Chivu-Economescu, M., Dragu, D. L., Necula, L. G., Matei, L., Enciu, A. M., Bleotu, C., & Diaconu, C. C. (2017). Knockdown of KRT17 by siRNA induces antitumoral effects on gastric cancer cells. Gastric Cancer, 20(6), 948-959.
Figure 3 Expression of KRT17 in conventional RCC.
Strong KRT17 expression in single tumor cells.
Sarlos, D. P., Yusenko, M. V., Peterfi, L., Szanto, A., & Kovacs, G. (2019). Dual role of KRT17: development of papillary renal cell tumor and progression of conventional renal cell carcinoma. Journal of Cancer, 10(21), 5124.
Figure 4 Effect of Krt17 on the cell cycle and apoptosis in GC cells.
Downregulation of Krt17 significantly increased apoptosis in SGC-7901 cells.
Hu, H., Xu, D. H., Huang, X. X., Zhu, C. C., Xu, J., Zhang, Z. Z., & Zhao, G. (2018). Keratin17 promotes tumor growth and is associated with poor prognosis in gastric cancer. Journal of Cancer, 9(2), 346.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
---|---|---|---|
MOR-1981 | Hi-Affi™ Recombinant Rabbit Anti-KRT17 Monoclonal Antibody (DS1981AB) | ICC/IF, IHC-P, IP, WB | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-0439-CN | Recombinant Mouse Anti-KRT17 Monoclonal Antibody (83-13) | WB, IF, IHC | Mouse IgG2a |
ZG-0461F | Mouse Anti-KRT17 Recombinant Antibody (ZG-0461F) | WB, IHC, ELISA | Mouse IgG |
ZG-0150J | Mouse Anti-KRT17 Recombinant Antibody (clone 10A1) | WB, IHC-P, IF/ICC, IP | Mouse IgG |
ZG-1024F | Mouse Anti-KRT17 Recombinant Antibody (clone E3) | FC, ICC, IHC-Fr, IHC-P, WB | Mouse IgG2b |
VS4-CJ5 | Recombinant Mouse Anti-KRT17 Antibody (VS4-CJ5) | ELISA, WB, IP | Mouse IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-J0153-YC-S(P) | Human Anti-KRT17 Recombinant Antibody (clone D1-1B2); scFv Fragment | ELISA, FC | Human scFv |
HPAB-J0154-YC-S(P) | Human Anti-KRT17 Recombinant Antibody (clone D3-5C); scFv Fragment | ELISA, FC | Human scFv |
HPAB-J0155-YC-S(P) | Human Anti-KRT17 Recombinant Antibody (clone D3-9D); scFv Fragment | ELISA, FC | Human scFv |
HPAB-J0156-YC-S(P) | Human Anti-KRT17 Recombinant Antibody (clone D3-12F); scFv Fragment | ELISA, FC | Human scFv |
FAMAB-0260JF-S(P) | Human Anti-KRT17 Recombinant Antibody (clone A4); scFv Fragment | IHC, WB, ELISA, FuncS | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-J0153-YC-F(E) | Human Anti-KRT17 Recombinant Antibody (clone D1-1B2); Fab Fragment | ELISA, FC | Human Fab |
HPAB-J0154-YC-F(E) | Human Anti-KRT17 Recombinant Antibody (clone D3-5C); Fab Fragment | ELISA, FC | Human Fab |
HPAB-J0155-YC-F(E) | Human Anti-KRT17 Recombinant Antibody (clone D3-9D); Fab Fragment | ELISA, FC | Human Fab |
HPAB-J0156-YC-F(E) | Human Anti-KRT17 Recombinant Antibody (clone D3-12F); Fab Fragment | ELISA, FC | Human Fab |
HPAB-J0157-YC-F(E) | Human Anti-KRT17 Recombinant Antibody (clone D3-6G); Fab Fragment | ELISA, FC | Human Fab |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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