Rabbit Anti-KRT17 Recombinant Antibody (VS13-YC633)
CAT#: VS13-YC633
The Rabbit Anti-KRT17 Recombinant Antibody is specific for human, mouse and rat KRT17. KRT17 encodes keratin 17, found in nail bed and hair follicles, with mutations leading to disorders like Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. The anti-KRT17 antibody can be used for Western blot (1/1000-1/2000), Immunofluorescence of cells (1/50), Immunofluorescence of tissues (1/200), Immunohistochemistry-paraffin (1/50-1/1500).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to intermediate filaments.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/453/27_B11_2_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line hTCEpi
Immunofluorescent staining of human cell line hTCEpi shows localization to intermediate filaments.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/452/1790_A8_1_selected.jpg
Normal Tissue
Figure 3 High expression in urinary bladder
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/453/1924_A_6_5_val_selected.jpg
Normal Tissue
Figure 4 Cerebral cortex
Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29/155820_B_8_5.jpg
RNA Expression
Figure 5 RNA cell line category: Group enriched (hTCEpi, SiHa)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000128422-KRT17
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Specifications
- Immunogen
- Recombinant human Cytokeratin 17, aa 1-50.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat KRT17
- Species Reactivity
- Human, Mouse, Rat
- Applications
- WB, IHC-P, ICC, IF
- Conjugate
- NONE
Product Property
- Clonality
- Monoclonal
- Purification
- Affinity Chromatography purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- TBS (pH 7.4) containing 40% Glycerol and 0.05% BSA.
- Preservative
- 0.05% Sodium azide
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Western blot (WB): 1/1000-1/2000
Immunofluorescence (IF-cell): 1/50
Immunofluorescence (IF-tissue): 1/200
Immunohistochemistry-paraffin (IHC-P): 1/50-1/1500
Target
- Alternative Names
- Keratin 17; Keratin 17, Type I; Cytokeratin-17; CK-17; 39.1; K17;
- Gene ID
- 3872
- UniProt ID
- Q04695 Q9QWL7 Mouse Q6IFU8 Rat
- Long Name
- Keratin 17
- Sequence Similarities
- Belongs to the intermediate filament family.
- Cellular Localization
- Cytoplasm; Intermediate filament; Keratin
- Protein Refseq
- NP_000413.1
- Function
- Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity).
Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity).
Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity).
Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial 'stem cells'. Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (By similarity).
May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "KRT17"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1242MZ | Recombinant Mouse Anti-Human KRT17 Antibody (clone Lt28.F4) | ICC, IF, IHC-Fr, IHC-P, WB | Mouse antibody |
| MRO-0439-CN | Recombinant Mouse Anti-KRT17 Monoclonal Antibody (83-13) | WB, IF, IHC | Mouse IgG2a |
| MRO-0440-CN | Recombinant Rabbit Anti-KRT17 Monoclonal Antibody (CBACN-179) | WB, IF, IHC, FC | Rabbit IgG |
| ZG-0150J | Mouse Anti-KRT17 Recombinant Antibody (clone 10A1) | WB, IHC-P, IF, ICC, IP | Mouse IgG |
| ZG-1024F | Mouse Anti-KRT17 Recombinant Antibody (clone E3) | FC, ICC, IHC-Fr, IHC-P, WB | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1981 | Hi-Affi™ Recombinant Rabbit Anti-KRT17 Monoclonal Antibody (DS1981AB) | ICC, IF, IHC-P, IP, WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-J0153-YC-S(P) | Human Anti-KRT17 Recombinant Antibody (clone D1-1B2); scFv Fragment | ELISA, FC | Human scFv |
| HPAB-J0154-YC-S(P) | Human Anti-KRT17 Recombinant Antibody (clone D3-5C); scFv Fragment | ELISA, FC | Human scFv |
| HPAB-J0155-YC-S(P) | Human Anti-KRT17 Recombinant Antibody (clone D3-9D); scFv Fragment | ELISA, FC | Human scFv |
| HPAB-J0156-YC-S(P) | Human Anti-KRT17 Recombinant Antibody (clone D3-12F); scFv Fragment | ELISA, FC | Human scFv |
| HPAB-J0157-YC-S(P) | Human Anti-KRT17 Recombinant Antibody (clone D3-6G); scFv Fragment | ELISA, FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-J0153-YC-F(E) | Human Anti-KRT17 Recombinant Antibody (clone D1-1B2); Fab Fragment | ELISA, FC | Human Fab |
| HPAB-J0154-YC-F(E) | Human Anti-KRT17 Recombinant Antibody (clone D3-5C); Fab Fragment | ELISA, FC | Human Fab |
| HPAB-J0155-YC-F(E) | Human Anti-KRT17 Recombinant Antibody (clone D3-9D); Fab Fragment | ELISA, FC | Human Fab |
| HPAB-J0156-YC-F(E) | Human Anti-KRT17 Recombinant Antibody (clone D3-12F); Fab Fragment | ELISA, FC | Human Fab |
| HPAB-J0157-YC-F(E) | Human Anti-KRT17 Recombinant Antibody (clone D3-6G); Fab Fragment | ELISA, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY168 | AbPlus™ Anti-KRT17 Magnetic Beads (10A1) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1212 | Anti-KRT17 Immunohistochemistry Kit | IHC | |
| VS-0525-XY3852 | Anti-Rat KRT17 Immunohistochemistry Kit | IHC | |
| VS-0525-XY3853 | Anti-Mouse KRT17 Immunohistochemistry Kit | IHC | |
| VS-0525-XY3851 | Anti-Human KRT17 Immunohistochemistry Kit | IHC |
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