CytoStream™ Rabbit Anti-LAMB1 Recombinant Antibody (VS13-YC642) (CAT#: VS13-YC642)
The CytoStream™ Rabbit Anti-LAMB1 Recombinant Antibody is specific for human and mouse LAMB1. LAMB1 encodes laminin beta subunit, part of matrices involved in adhesion, migration, and signaling during development. It displays unique chain and domain structures, affecting basement membrane integrity and neuronal migration, with involvement in laminin-1 formation. The anti-LAMB1 antibody was developed and selected by our CytoStream™ platform and the mAb is recommended for use in flow cytometry staining (1/50-1/100).
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 IHC staining of human placenta
(Immunohistochemical staining of human placenta shows strong cytoplasmic and membranous positivity in trophoblastic cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4056/13514_A_2_7_selected.jpg
(Immunohistochemical staining of human placenta shows strong cytoplasmic and membranous positivity in trophoblastic cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4056/13514_A_2_7_selected.jpg
Figure 2 IHC staining of human tonsil
(Low expression. RNA expression: 5.2 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4132/12669_A_4_8_val_selected.jpg
(Low expression. RNA expression: 5.2 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4132/12669_A_4_8_val_selected.jpg
Figure 3 Cerebral cortex
(Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranou)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4256/14034_B_8_5.jpg
(Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranou)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4256/14034_B_8_5.jpg
Figure 4 Colon
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Enterocytes
Staining: High
Intensity: Strong
Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4256/14034_A_9_3.jpg
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Enterocytes
Staining: High
Intensity: Strong
Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4256/14034_A_9_3.jpg
Figure 5 Liver
(Hepatocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4056/13514_A_8_4.jpg
(Hepatocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4056/13514_A_8_4.jpg
Figure 6 Kidney
(Cells in tubules
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4256/14034_A_8_5.jpg
(Cells in tubules
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4256/14034_A_8_5.jpg
Figure 7 Testis
(Leydig cells
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4256/14034_A_6_6.jpg
(Leydig cells
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4256/14034_A_6_6.jpg
Figure 8 Lymph node
(Germinal center cells
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Not detected
Intensity: Weak
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4056/13514_A_7_8.jpg
(Germinal center cells
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Not detected
Intensity: Weak
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4056/13514_A_7_8.jpg
Figure 9 RNA cell line category: Cell line enhanced (ASC diff, ASC TERT1, HSkMC, TIME)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000091136-LAMB1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000091136-LAMB1
Specifications
- Immunogen
- Recombinant human Laminin beta 1, aa 1721-1769.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human and Mouse LAMB1
- Species Reactivity
- Human, Mouse
- Applications
- WB, IHC-P, FC
- Conjugate
- NONE
- Related Disease
- Lissencephaly and Cutis Laxa, Neonatal, With Marfanoid Phenotype
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- TBS (pH 7.4) containing 40% Glycerol and 0.05% BSA.
- Preservative
- 0.05% Sodium azide
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Western blot (WB): 1/500-1/2000
Immunohistochemistry-paraffin (IHC-P): 1/50-1/200
Flow cytometry (FC): 1/50-1/100
Target
- Alternative Names
- Laminin Subunit Beta 1; Laminin B1 Chain; Laminin, Beta 1; Cutis Laxa With Marfanoid Phenotype;Laminin-10 Subunit Beta; Laminin-12 Subunit Beta; Laminin Subunit Beta-1; Laminin-1 Subunit Beta; Laminin-2 Subunit Beta; Laminin-6 Subunit Beta; Laminin-8 Subunit Beta
- Gene ID
- 3912
- UniProt ID
- P07942
- Long Name
- Laminin Subunit Beta 1
- Cellular Localization
- Secreted; Basement membrane
- Protein Refseq
- XP_047276316.1
- Function
- Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
Involved in the organization of the laminar architecture of cerebral cortex.
It is probably required for the integrity of the basement membrane/glia limitans that serves as an anchor point for the endfeet of radial glial cells and as a physical barrier to migrating neurons.
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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Rabbit Monoclonal Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3328z | Mouse Anti-LAMB1 Recombinant Antibody (clone 39H2) | ELISA, IHC, WB | Mouse IgG2a |
| MOB-1059CT | Recombinant Mouse anti-Human LAMB1 Monoclonal antibody (EH20) | AP, WB | |
| VS3-XY1001 | Mouse Anti-LAMB1 Recombinant Antibody (clone 2D9G5) | ELISA, WB, IHC | Mouse IgG2a |
| VS3-XY3415 | Rabbit Anti-LAMB1 Recombinant Antibody (clone R08-7I6) | WB, FC | Rabbit IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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