Rabbit Anti-LAMB1 Recombinant Antibody (clone R08-7I6)
CAT#: VS3-XY3415
It is a recombinant rabbit antibody specific for LAMB1 (Laminin subunit beta 1), which involves in the organization of the laminar architecture of cerebral cortex. It specifically targets human, mouse and rat LAMB1. This product has been tested using Western Blot and Flow cytometry.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human placenta
Immunohistochemical staining of human placenta shows strong cytoplasmic and membranous positivity in trophoblastic cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4056/13514_A_2_7_selected.jpg
Normal Tissue
Figure 2 IHC staining of human tonsil
Low expression. RNA expression: 5.2 nTPM
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4132/12669_A_4_8_val_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranou
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4256/14034_B_8_5.jpg
Normal Tissue
Figure 4 Colon
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Enterocytes
Staining: High
Intensity: Strong
Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4256/14034_A_9_3.jpg
Normal Tissue
Figure 5 Liver
Hepatocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4056/13514_A_8_4.jpg
Normal Tissue
Figure 6 Kidney
Cells in tubules
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4256/14034_A_8_5.jpg
Normal Tissue
Figure 7 Testis
Leydig cells
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4256/14034_A_6_6.jpg
Normal Tissue
Figure 8 Lymph node
Germinal center cells
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Not detected
Intensity: Weak
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4056/13514_A_7_8.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced (ASC diff, ASC TERT1, HSkMC, TIME)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000091136-LAMB1
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Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat LAMB1
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R08-7I6
- Applications
- WB, FC
- Related Disease
- Lissencephaly 5; Cutis Laxa
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
FC: 1/50-1/100
Target
- Alternative Names
- CLM; LIS5
- Gene ID
- 3912
- UniProt ID
- P07942
- Long Name
- Laminin subunit beta 1
- Cellular Localization
- Secreted, Basement membrane
- Post Translation Modifications
- Glycosylation at Asn120, Asn330, Asn356, Asn519, Asn677, Asn1041, Asn1195, Asn1279, Asn1336, Asn1343, Thr1435, Asn1487, Asn1542, and Asn1643 (NX_P07942 [NX_P07942-1])
Modification sites at PhosphoSitePlus (P07942)
Glycosylation from GlyConnect LAMB1_HUMAN (1442)
Glycosylation from GlyGen (P07942) 16 sites, 33 N-linked glycans (6 sites), 2 O-linked glycans (4 sites)
- Protein Refseq
- XP_047276316.1
- Function
- Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
Involved in the organization of the laminar architecture of cerebral cortex.
It is probably required for the integrity of the basement membrane/glia limitans that serves as an anchor point for the endfeet of radial glial cells and as a physical barrier to migrating neurons.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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- Product Name
Recommended Dilution Buffer
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Secondary Antibody
- CAT
- Product Name
See other products for "LAMB1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3328z | Mouse Anti-LAMB1 Recombinant Antibody (clone 39H2) | ELISA, IHC, WB | Mouse IgG2a |
| MOB-1059CT | Recombinant Mouse anti-Human LAMB1 Monoclonal antibody (EH20) | AP, WB | |
| VS3-XY1001 | Mouse Anti-LAMB1 Recombinant Antibody (clone 2D9G5) | ELISA, WB, IHC | Mouse IgG2a |
| VS7-0425-WR279 | Mouse Anti-LAMB1 Monoclonal Antibody (VS7-0425-WR279) | WB, IHC-P, IF, ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2005 | Hi-Affi™ Recombinant Rabbit Anti-LAMB1 Monoclonal Antibody (DS2005AB) | WB, FC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS13-YC642 | CytoStream™ Rabbit Anti-LAMB1 Recombinant Antibody (VS13-YC642) | WB, IHC-P, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3926 | Anti-LAMB1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY3927 | Anti-Mouse LAMB1 Immunohistochemistry Kit | IHC |
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