Rabbit Anti-LAMB1 Recombinant Antibody (clone R08-7I6) (CAT#: VS3-XY3415)
It is a recombinant rabbit antibody specific for LAMB1 (Laminin subunit beta 1), which involves in the organization of the laminar architecture of cerebral cortex. It specifically targets human, mouse and rat LAMB1. This product has been tested using Western Blot and Flow cytometry.
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Normal Tissue
RNA Expression
Figure 1 IHC staining of human placenta
(Immunohistochemical staining of human placenta shows strong cytoplasmic and membranous positivity in trophoblastic cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4056/13514_A_2_7_selected.jpg
(Immunohistochemical staining of human placenta shows strong cytoplasmic and membranous positivity in trophoblastic cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4056/13514_A_2_7_selected.jpg
Figure 2 IHC staining of human tonsil
(Low expression. RNA expression: 5.2 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4132/12669_A_4_8_val_selected.jpg
(Low expression. RNA expression: 5.2 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4132/12669_A_4_8_val_selected.jpg
Figure 3 Cerebral cortex
(Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranou)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4256/14034_B_8_5.jpg
(Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranou)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4256/14034_B_8_5.jpg
Figure 4 Colon
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Enterocytes
Staining: High
Intensity: Strong
Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4256/14034_A_9_3.jpg
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Enterocytes
Staining: High
Intensity: Strong
Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4256/14034_A_9_3.jpg
Figure 5 Liver
(Hepatocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4056/13514_A_8_4.jpg
(Hepatocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4056/13514_A_8_4.jpg
Figure 6 Kidney
(Cells in tubules
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4256/14034_A_8_5.jpg
(Cells in tubules
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4256/14034_A_8_5.jpg
Figure 7 Testis
(Leydig cells
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4256/14034_A_6_6.jpg
(Leydig cells
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4256/14034_A_6_6.jpg
Figure 8 Lymph node
(Germinal center cells
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Not detected
Intensity: Weak
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4056/13514_A_7_8.jpg
(Germinal center cells
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Not detected
Intensity: Weak
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4056/13514_A_7_8.jpg
Figure 9 RNA cell line category: Cell line enhanced (ASC diff, ASC TERT1, HSkMC, TIME)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000091136-LAMB1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000091136-LAMB1
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat LAMB1
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R08-7I6
- Applications
- WB, FC
- Related Disease
- Lissencephaly 5; Cutis Laxa
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
FC: 1/50-1/100
Target
- Alternative Names
- CLM; LIS5
- Gene ID
- 3912
- UniProt ID
- P07942
- Long Name
- Laminin subunit beta 1
- Cellular Localization
- Secreted, Basement membrane
- Post Translation Modifications
- Glycosylation at Asn120, Asn330, Asn356, Asn519, Asn677, Asn1041, Asn1195, Asn1279, Asn1336, Asn1343, Thr1435, Asn1487, Asn1542, and Asn1643 (NX_P07942 [NX_P07942-1])
Modification sites at PhosphoSitePlus (P07942)
Glycosylation from GlyConnect LAMB1_HUMAN (1442)
Glycosylation from GlyGen (P07942) 16 sites, 33 N-linked glycans (6 sites), 2 O-linked glycans (4 sites)
- Protein Refseq
- XP_047276316.1
- Function
- Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
Involved in the organization of the laminar architecture of cerebral cortex.
It is probably required for the integrity of the basement membrane/glia limitans that serves as an anchor point for the endfeet of radial glial cells and as a physical barrier to migrating neurons.
Recommended Products
Isotype Control
Recommended Dilution Buffer
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IHC Kits & Antibodies
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3328z | Mouse Anti-LAMB1 Recombinant Antibody (clone 39H2) | ELISA, IHC, WB | Mouse IgG2a |
| MOB-1059CT | Recombinant Mouse anti-Human LAMB1 Monoclonal antibody (EH20) | AP, WB | |
| VS3-XY1001 | Mouse Anti-LAMB1 Recombinant Antibody (clone 2D9G5) | ELISA, WB, IHC | Mouse IgG2a |
| VS7-0425-WR279 | Mouse Anti-LAMB1 Monoclonal Antibody (VS7-0425-WR279) | WB, IHC-P, IF, ELISA | Mouse IgG |
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