Rabbit Anti-LMAN1 Recombinant Antibody (clone R01-8R1) (CAT#: VS3-XY3418)
It is a recombinant rabbit antibody targeting the LMAN1 (Lectin, mannose binding 1), which may recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors. It recognizes and binds to human LMAN1. It also has cross-reactivity against mouse and rat LMAN1. It has been determined using Western Blot, Immunohistochemistry-Paraffin, Immunocytochemistry or Immunofluorescence.
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Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line EFO-21
(Immunofluorescent staining of human cell line EFO-21 shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37163/2063_G6_7_selected.jpg
(Immunofluorescent staining of human cell line EFO-21 shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37163/2063_G6_7_selected.jpg
Figure 2 IHC staining of human duodenum
(Immunohistochemical staining of human duodenum shows strong cytoplasmic positivity with granular pattern in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2320/ihc_selected.jpg
(Immunohistochemical staining of human duodenum shows strong cytoplasmic positivity with granular pattern in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2320/ihc_selected.jpg
Figure 3 IHC staining of human breast
(Immunohistochemical staining of human breast shows strong cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37163/ihc_selected.jpg
(Immunohistochemical staining of human breast shows strong cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37163/ihc_selected.jpg
Figure 4 Cerebral cortex
(Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37163/85396_B_8_5.jpg
(Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37163/85396_B_8_5.jpg
Figure 5 Thyroid gland
(Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37163/85396_B_3_5.jpg
(Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37163/85396_B_3_5.jpg
Figure 6 Colon
(Endocrine cells
Staining: High
Intensity: Strong
Enterocytes
Staining: High
Intensity: Strong
Quantity: 75%-25%
Goblet cells
Staining: High
Intensity: Strong
Quantity:>75%
Mucosal lymphoid cells
Staining: High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37163/85396_A_9_3.jpg
(Endocrine cells
Staining: High
Intensity: Strong
Enterocytes
Staining: High
Intensity: Strong
Quantity: 75%-25%
Goblet cells
Staining: High
Intensity: Strong
Quantity:>75%
Mucosal lymphoid cells
Staining: High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37163/85396_A_9_3.jpg
Figure 7 Liver
(Cholangiocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Hepatocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37163/85396_A_8_4.jpg
(Cholangiocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Hepatocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37163/85396_A_8_4.jpg
Figure 8 Kidney
(Cells in glomeruli
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37163/85396_A_9_5.jpg
(Cells in glomeruli
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37163/85396_A_9_5.jpg
Figure 9 Testis
(Leydig cells
Staining: High
Intensity: Strong
Quantity:>75%
Sertoli cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37163/85396_A_6_6.jpg
(Leydig cells
Staining: High
Intensity: Strong
Quantity:>75%
Sertoli cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37163/85396_A_6_6.jpg
Figure 10 Lymph node
(Non-germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37163/85396_A_9_8.jpg
(Non-germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37163/85396_A_9_8.jpg
Figure 11 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000074695-LMAN1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000074695-LMAN1
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat LMAN1
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R01-8R1
- Applications
- WB, IHC-P, ICC, IF
- Related Disease
- Factor V And Factor Viii, Combined Deficiency of, 2
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IHC: 1/50-1/100
IF: 1/50-1/200
Target
- Alternative Names
- MR60; gp58; F5F8D; FMFD1; MCFD1; ERGIC53; ERGIC-53
- Gene ID
- 3998
- UniProt ID
- P49257
- Long Name
- Lectin, mannose binding 1
- Cellular Localization
- Golgi apparatus membrane, Endoplasmic reticulum membrane
- Post Translation Modifications
- The N-terminal may be partly blocked. (P49257-LMAN1_HUMAN)
Glycosylation at Thr276, Thr385, Ser425, Thr432, and Thr433 (NX_P49257 [NX_P49257-1])
Ubiquitination at Lys346 and Lys372 (NX_P49257 [NX_P49257-1])
Modification sites at PhosphoSitePlus (P49257)
Glycosylation from GlyGen (P49257) 9 sites, 5 O-linked glycans (9 sites)
- Protein Refseq
- NP_005561.1
- Function
- Mannose-specific lectin.
May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both.
The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins.
Recommended Products
Isotype Control
Recommended Dilution Buffer
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2385z | Mouse Anti-LMAN1 Recombinant Antibody (clone 15A2) | WB, FC, ICC, IF, IHC | Mouse IgG1 |
| VS3-FY849 | Recombinant Rabbit Anti-LMAN1 Antibody (clone R03-5C3) | WB, IHC-P | Rabbit IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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