Mouse Anti-LSR Recombinant Antibody Hexamer (VS-0924-YC137), CDC Enhanced (CAT#: VS-0924-YC137)

The product is a mouse anti-LSR antibody hexamer with enhanced complement-dependent cytotoxicity (CDC) activity. This hexameric IgG1 targets human LSR and contains hexamerization-enhancing mutations, which promote hexamer formation, thereby mediating optimal C1q binding and enhancing CDC.

Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression

Specifications

  • Immunogen
  • Human LSR protein ECD domain
  • Host Species
  • Mouse
  • Type
  • Antibody hexamer
  • Specificity
  • Human LSR
  • Species Reactivity
  • Human
  • Molecule Class
  • ~ 900 kDa
  • Applications
  • FC, WB, BI, ELISA, CDC
  • Conjugate
  • None
  • Related Disease
  • Autoimmune diseases, inflammatory diseases, transplant rejection

Product Property

  • Clonality
  • Monoclonal
  • Purification
  • Protein G purified
  • Purity
  • >95% determined as SDS-PAGE and SEC-HPLC
  • Aggregation
  • <5%
  • Buffer
  • PBS, pH 7.4
  • Preservative
  • No preservatives
  • Storage
  • Store at 4°C short term (1-2 weeks). Store at -20°C long term (12 months). Avoid repeated freeze/thaw cycles.

Target

  • Alternative Names
  • LSR; lipolysis stimulated lipoprotein receptor; ILDR3; LISCH7; lipolysis-stimulated lipoprotein receptor; LISCH protein; lipolysis-stimulated remnant; liver-specific bHLH-Zip transcription factor; immunoglobulin-like domain containing receptor 3
  • Long Name
  • Lipolysis Stimulated Lipoprotein Receptor
  • Sequence Similarities
  • Belongs to the immunoglobulin superfamily. LISCH7 family.
  • Cellular Localization
  • Cell membrane; Single-pass type I membrane protein {ECO:0000269 PubMed:21245199 | ECO:0000255}
    Cell junction, tight junction {ECO:0000269 PubMed:21245199, 23239027}
  • Post Translation Modifications
  • Phosphorylation at Ser-365 by MAPK8/JNK1 and MAPK9/JNK2 may be required for exclusive localization at tricellular tight junstions. ( Q86X29-LSR_HUMAN )
    Ubiquitination at Lys410 ( NX_Q86X29 [NX_Q86X29-1] )
  • Function
  • Probable role in the clearance of triglyceride-rich lipoprotein from blood.
    Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity).
    Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (By similarity).

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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