Mouse Anti-LSR Recombinant Antibody Hexamer (VS-0924-YC137), CDC Enhanced
CAT#: VS-0924-YC137
The product is a mouse anti-LSR antibody hexamer with enhanced complement-dependent cytotoxicity (CDC) activity. This hexameric IgG1 targets human LSR and contains hexamerization-enhancing mutations, which promote hexamer formation, thereby mediating optimal C1q binding and enhancing CDC.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line A431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/75309/1833_E6_1_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human stomach
Immunohistochemical staining of human stomach shows strong cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/7270/ihc_selected.jpg
Subcellular Location and Protein Expression
Figure 3 IF staining of human cell line RT4
Immunofluorescent staining of human cell line RT4 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/75309/1805_E4_1_blue_red_green.jpg
Subcellular Location and Protein Expression
Figure 4 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/75309/1893_C12_13_cr5bc43ebeb8447_blue_red_green.jpg
Normal Tissue
Figure 5 Cerebral cortex
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Neuronal cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/7270/18307_B_7_5.jpg
Normal Tissue
Figure 6 Colon
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/7270/18307_A_7_3.jpg
Normal Tissue
Figure 7 Liver
Cholangiocytes
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/7270/18307_A_8_4.jpg
Normal Tissue
Figure 8 Testis
Cells in seminiferous ducts
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/7270/18307_A_6_6.jpg
Normal Tissue
Figure 9 Lymph node
Germinal center cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/7270/18307_A_8_8.jpg
RNA Expression
Figure 10 RNA cell line category: Cell line enhanced (A-431, CACO-2, CAPAN-2, HaCaT, OE19, RT4)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000105699-LSR
❮
❯
Specifications
- Immunogen
- Human LSR protein ECD domain
- Host Species
- Mouse
- Type
- Antibody hexamer
- Specificity
- Human LSR
- Species Reactivity
- Human
- Molecule Class
- ~ 900 kDa
- Applications
- FC, WB, BI, ELISA, CDC
- Conjugate
- None
- Related Disease
- Autoimmune diseases, inflammatory diseases, transplant rejection
Product Property
- Clonality
- Monoclonal
- Purification
- Protein G purified
- Purity
- >95% determined as SDS-PAGE and SEC-HPLC
- Aggregation
- <5%
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term (1-2 weeks). Store at -20°C long term (12 months). Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- LSR; lipolysis stimulated lipoprotein receptor; ILDR3; LISCH7; lipolysis-stimulated lipoprotein receptor; LISCH protein; lipolysis-stimulated remnant; liver-specific bHLH-Zip transcription factor; immunoglobulin-like domain containing receptor 3
- Gene ID
- 51599
- UniProt ID
- Q86X29
- Long Name
- Lipolysis Stimulated Lipoprotein Receptor
- Sequence Similarities
- Belongs to the immunoglobulin superfamily. LISCH7 family.
- Cellular Localization
- Cell membrane; Single-pass type I membrane protein {ECO:0000269 PubMed:21245199 | ECO:0000255}
Cell junction, tight junction {ECO:0000269 PubMed:21245199, 23239027}
- Post Translation Modifications
- Phosphorylation at Ser-365 by MAPK8/JNK1 and MAPK9/JNK2 may be required for exclusive localization at tricellular tight junstions. ( Q86X29-LSR_HUMAN )
Ubiquitination at Lys410 ( NX_Q86X29 [NX_Q86X29-1] )
- Function
- Probable role in the clearance of triglyceride-rich lipoprotein from blood.
Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity).
Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (By similarity).
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COA
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| HPAB-AP136-YC-S(P) | Mouse Anti-LSR Recombinant Antibody (clone 8C8); scFv Fragment | FC, CDC | Mouse scFv |
| HPAB-AP137-YC-S(P) | Human Anti-LSR Recombinant Antibody (clone S11-01.E02); scFv Fragment | FC, CDC | Human scFv |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC136 | Human Anti-LSR Recombinant Antibody Hexamer (VS-0924-YC136), CDC Enhanced | FC, CDC | Antibody hexamer |
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