Human Anti-LSR Recombinant Antibody Hexamer (VS-0924-YC136), CDC Enhanced (CAT#: VS-0924-YC136)

• Host Species
• Human

• Type
• Antibody hexamer

• Specificity
• Human LSR

• Species Reactivity
• Human

• Molecule Class
• ~ 900 kDa

• Applications
• FC, CDC

• Conjugate
• None

• Clonality
• Monoclonal

• Purification
• Protein A purified

• Purity
• >95% determined as SDS-PAGE and SEC-HPLC

• Aggregation
• <5%

• Buffer
• PBS, pH 7.4

• Preservative
• No preservatives

• Storage
• Store at 4°C short term (1-2 weeks). Store at -20°C long term (12 months). Avoid repeated freeze/thaw cycles.

• Alternative Names
• ILDR3; LISCH7

• Gene ID
• 51599

• UniProt ID
• Q86X29

• Long Name
• Lipolysis Stimulated Lipoprotein Receptor

• Sequence Similarities
• Belongs to the immunoglobulin superfamily. LISCH7 family.

• Cellular Localization
• Cell membrane; Single-pass type I membrane protein {ECO:0000269 PubMed:21245199 | ECO:0000255}
  Cell junction, tight junction {ECO:0000269 PubMed:21245199, 23239027}

• Post Translation Modifications
• Phosphorylation at Ser-365 by MAPK8/JNK1 and MAPK9/JNK2 may be required for exclusive localization at tricellular tight junstions. ( Q86X29-LSR_HUMAN )
  Ubiquitination at Lys410 ( NX_Q86X29 [NX_Q86X29-1] )

• Function
• Probable role in the clearance of triglyceride-rich lipoprotein from blood.
  Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity).
  Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (By similarity).

Select a product category from the dropdown menu below to view related products.