Rabbit Anti-MAP3K7 Recombinant Antibody (clone R09-4G4)
CAT#: VS3-XY3426
It is a recombinant rabbit antibody specific for MAP3K7 (Mitogen-activated protein kinase kinase kinase 7), which plays an important role in the cascades of cellular responses. It specifically targets human, mouse and rat MAP3K7. This product has been tested using Western Blot, Immunohistochemistry-Paraffin, Flow cytometry, Immunocytochemistry or Immunofluorescence.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to nuclear speckles & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7633/if_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line SH-SY5Y
Immunofluorescent staining of human cell line SH-SY5Y shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/75335/1835_D4_7_selected.jpg
Normal Tissue
Figure 3 IHC staining of human stomach
Immunohistochemical staining of human stomach shows strong cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7633/21509_A_4_1_selected.jpg
Normal Tissue
Figure 4 Cerebral cortex
Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Glial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7633/21509_B_9_5.jpg
RNA Expression
Figure 5 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000135341-MAP3K7
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Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat MAP3K7
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R09-4G4
- Applications
- WB, IHC-P, ICC, IF, FC
- Related Disease
- Cardiospondylocarpofacial Syndrome; Frontometaphyseal Dysplasia 2
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IHC: 1/50-1/100
IF: 1/50-1/200
FC: 1/50-1/100
Target
- Alternative Names
- CSCF; FMD2; TAK1; MEKK7; TGF1a
- Gene ID
- 6885
- UniProt ID
- O43318
- Long Name
- Mitogen-activated protein kinase kinase kinase 7
- Cellular Localization
- Cytoplasm, Cell membrane
- Post Translation Modifications
- (Microbial infection) Acetylation of Thr-184 and Thr-187 by Yersinia YopJ prevents phosphorylation and activation, thus blocking the MAPK signaling pathway. (O43318-M3K7_HUMAN)
Ubiquitination at Lys72, Lys158, Lys209, and Lys547 (NX_O43318 [NX_O43318-1])
Modification sites at PhosphoSitePlus (O43318)
Glycosylation from GlyGen (O43318) 3 sites, 1 O-linked glycan (3 sites)
- Protein Refseq
- XP_054212245.1
- Function
- Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway.
Plays an important role in the cascades of cellular responses evoked by changes in the environment.
Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR).
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Related Diseases
Endometrial Cancer
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Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "MAP3K7"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2143 | Hi-Affi™ Recombinant Rabbit Anti-MAP3K7 Monoclonal Antibody (DS2143AB) | WB, IHC-P, ICC | IgG |
| MOR-4749 | Hi-Affi™ Recombinant Rabbit Anti-MAP3K7 Monoclonal Antibody (TH263DS) | WB, IF, ICC, FC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-XY1033 | Mouse Anti-MAP3K7 Recombinant Antibody (clone 1G5) | WB, IP, IF | Mouse IgG1 |
| VS3-XY1034 | Mouse Anti-MAP3K7 Recombinant Antibody (clone 1H6H6) | ELISA, WB | Mouse IgG2a |
| VS3-XY1035 | Mouse Anti-MAP3K7 Recombinant Antibody (clone 4E7E10) | ELISA, WB | Mouse IgG2a |
| VS3-FY883 | Recombinant Rabbit Anti-MAP3K7 (phospho Ser439) Antibody (clone R07-7K2) | WB, ICC, IF, IP | Rabbit IgG |
| VS3-WK2277 | Rabbit Anti-MAP3K7 (pS439) Recombinant Antibody (VS3-WK2277) | WB, ICC, IP | Rabbit IgG |
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