Rabbit Anti-MAP3K7 Recombinant Antibody (clone R09-4G4) (CAT#: VS3-XY3426)
It is a recombinant rabbit antibody specific for MAP3K7 (Mitogen-activated protein kinase kinase kinase 7), which plays an important role in the cascades of cellular responses. It specifically targets human, mouse and rat MAP3K7. This product has been tested using Western Blot, Immunohistochemistry-Paraffin, Flow cytometry, Immunocytochemistry or Immunofluorescence.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to nuclear speckles & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/7633/if_selected.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to nuclear speckles & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/7633/if_selected.jpg
Figure 2 IF staining of human cell line SH-SY5Y
(Immunofluorescent staining of human cell line SH-SY5Y shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/75335/1835_D4_7_selected.jpg
(Immunofluorescent staining of human cell line SH-SY5Y shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/75335/1835_D4_7_selected.jpg
Figure 3 IHC staining of human stomach
(Immunohistochemical staining of human stomach shows strong cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/7633/21509_A_4_1_selected.jpg
(Immunohistochemical staining of human stomach shows strong cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/7633/21509_A_4_1_selected.jpg
Figure 4 Cerebral cortex
(Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Glial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/7633/21509_B_9_5.jpg
(Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Glial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/7633/21509_B_9_5.jpg
Figure 5 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000135341-MAP3K7
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000135341-MAP3K7
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat MAP3K7
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R09-4G4
- Applications
- WB, IHC-P, ICC, IF, FC
- Related Disease
- Cardiospondylocarpofacial Syndrome; Frontometaphyseal Dysplasia 2
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IHC: 1/50-1/100
IF: 1/50-1/200
FC: 1/50-1/100
Target
- Alternative Names
- CSCF; FMD2; TAK1; MEKK7; TGF1a
- Gene ID
- 6885
- UniProt ID
- O43318
- Long Name
- Mitogen-activated protein kinase kinase kinase 7
- Cellular Localization
- Cytoplasm, Cell membrane
- Post Translation Modifications
- (Microbial infection) Acetylation of Thr-184 and Thr-187 by Yersinia YopJ prevents phosphorylation and activation, thus blocking the MAPK signaling pathway. (O43318-M3K7_HUMAN)
Ubiquitination at Lys72, Lys158, Lys209, and Lys547 (NX_O43318 [NX_O43318-1])
Modification sites at PhosphoSitePlus (O43318)
Glycosylation from GlyGen (O43318) 3 sites, 1 O-linked glycan (3 sites)
- Protein Refseq
- XP_054212245.1
- Function
- Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway.
Plays an important role in the cascades of cellular responses evoked by changes in the environment.
Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR).
Recommended Products
Isotype Control
Recommended Dilution Buffer
Secondary Antibody
Related Resources
Endometrial Cancer
Throid Cancer
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "MAP3K7"
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Please select product type
Rabbit Monoclonal Antibody Products
IgG Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2143 | Hi-Affi™ Recombinant Rabbit Anti-MAP3K7 Monoclonal Antibody (DS2143AB) | WB, IHC-P, ICC | IgG |
| MOR-4749 | Hi-Affi™ Recombinant Rabbit Anti-MAP3K7 Monoclonal Antibody (TH263DS) | WB, IF, ICC, FC | IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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