AbPlus™ Anti-MAPK14 Magnetic Beads (VS-0724-YC1292)
CAT#: VS-0724-YC1292
The AbPlus Anti-MAPK14 Magnetic Beads (VS-0724-YC1292) is an innovative affinity resin which is bound with anti-MAPK14 specific antibody. The beads were designed for small-scale affinity purification and immunoprecipitation (IP) of MAPK14 protein under native and denaturing conditions.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nuclear speckles & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/51825/834_A12_2_selected.jpg
Normal Tissue
Figure 2 Lymph node
Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/40578/149032_A_8_8.jpg
Normal Tissue
Figure 3 Liver
Hepatocytes Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/40578/149032_A_7_4.jpg
Normal Tissue
Figure 4 Kidney
Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/40578/149032_A_8_5.jpg
Normal Tissue
Figure 5 Testis
Sertoli cells Staining: Medium Intensity: Moderate Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/40578/149032_A_6_6.jpg
Normal Tissue
Figure 6 Bone marrow
Hematopoietic cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/40578/149032_B_5_4.jpg
RNA Expression
Figure 7 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000112062-MAPK14
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Specifications
- Applications
- Immunoprecipitation, Protein Purification
- Matrix
- Magnetic bead
- Bead Ligand
- Anti-MAPK14 specific antibody
- Target
- MAPK14
- Immunogen
- Recombinant human p38 alpha/MAPK14, aa 1-360.
- Target Species
- Human
- Bead Capacity
- 40 mg/mL
- Bead size
- 25 μm
- Format
- Suspension
- Concentration
- 2 mg/mL
- Buffer
- PBS, pH 7.4
- Preservative
- 0.1% Sodium azide
- Storage
- Stored at 4°C, and is stable for up to 2 years. Do not centrifuge, dry or freeze the magnetic beads.
Applications
- Application Notes
- The beads are in suspension and will settle upon storage. Prior to use, mix the vial gently (do not vortex) to ensure delivery of proper bead volume.
Target
- Introduction
- The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
- Alternative Names
- Mitogen-Activated Protein Kinase 14; Mitogen-Activated Protein Kinase P38 Alpha; MAX-Interacting Protein 2; CSAID-Binding Protein; MAP Kinase P38 Alpha; P38 MAP Kinase; MAP Kinase 14; EC 2.7.11.24; SAPK2A; CSBP1; CSBP2; CSPB1; CSBP; Mxi2; Cytokine Suppressive Anti-Inflammatory Drug Binding Protein; Cytokine Suppressive Anti-Inflammatory Drug-Binding Protein;
- Gene ID
- 1432
- UniProt ID
- Q16539
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Related Signaling Pathways
FcεR1 Signaling Pathway
TCR Signaling Pathway
Related Diseases
Maturity Onset Diabetes of the Young
Downloadable Resources
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "MAPK14"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1575z | Mouse Anti-MAPK14 Recombinant Antibody (clone 10H1) | WB, ELISA, FC, ICC, IF, IHC | Mouse IgG1 |
| MRO-1145-CN | Recombinant Rabbit Anti-MAPK14 Monoclonal Antibody (CBACN-417) | WB, IF | Rabbit IgG |
| MRO-1146-CN | Recombinant Rabbit Anti-MAPK14 Monoclonal Antibody (JF55-07) | WB, IF, IHC | Rabbit IgG |
| VS3-QX734 | Mouse Anti-MAPK14 Recombinant Antibody (clone 6F5-8A4-6G10) | IHC | Mouse IgG1 |
| VS3-QX735 | Mouse Anti-MAPK14 Recombinant Antibody (clone 8B3-4H8-6A8) | IHC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0512MZ | Chicken Anti-RK Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2153 | Hi-Affi™ Recombinant Rabbit Anti-MAPK14 Monoclonal Antibody (DS2153AB) | ELISA, WB | IgG |
| MOR-4696 | Hi-Affi™ Recombinant Rabbit Anti-MAPK14 Monoclonal Antibody (TH210DS) | WB, IHC-P | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4233 | Anti-MAPK14 Immunohistochemistry Kit | IHC | |
| VS-0525-XY4234 | Anti-Mouse MAPK14 Immunohistochemistry Kit | IHC | |
| VS-0525-XY4235 | Anti-Rat MAPK14 Immunohistochemistry Kit | IHC |
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