Anti-MERTK Antibody Prodrug, Protease Activated (VS-1025-YC128)
CAT#: VS-1025-YC128
The Anti-MERTK Antibody Prodrug, Protease Activated (VS-1025-YC128) is an antibody prodrug comprised of a recombinant mouse antibody targeting human MERTK, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to MERTK protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to MERTK effectively. MERTK (MER Proto-Oncogene, Tyrosine Kinase) is a receptor tyrosine kinase that is frequently overexpressed in various hematological malignancies, including acute myeloid leukemia (AML), promoting cell survival and inhibiting phagocytosis by immune cells. Its function in promoting an immunosuppressive state makes it an important target for therapeutic inhibition.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & endoplasmic reticulum.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/75622/1740_F11_62_selected.jpg
Normal Tissue
Figure 2 Adrenal gland
Glandular cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/36196/75498_B_6_5.jpg
Normal Tissue
Figure 3 Liver
Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/36196/75498_A_9_4.jpg
Normal Tissue
Figure 4 Kidney
Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/36196/75498_A_8_5.jpg
Normal Tissue
Figure 5 Testis
Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Spermatogonia cells Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/36196/75498_A_4_6.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (CACO-2, Hep G2, HUVEC TERT2, RT4)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000153208-MERTK
❮
❯
Specifications
- Host Animal
- Mouse
- Applications
- In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay
- Specificity
- Human MERTK
- Target
- MERTK
- Species Reactivity
- Human, Mouse
- Isotype
- IgG
- Epitope
- MERTK-ECD
- Masking Approach
- Affinity mask
- Mask
- A synthetic peptide
- Protease Cleavable Linker
- MMP-cleavable linker
- Protease Substrate
- MMPs
- Purification
- Protein A purified
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Target
- Introduction
- This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP).
- Alternative Names
- MER; RP38; c-Eyk; c-mer; Tyro12
- Gene ID
- 10461
- UniProt ID
- Q12866
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "MERTK"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-4080z | Mouse Anti-MERTK Recombinant Antibody (clone 28A5) | WB, ELISA, IP | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1466MZ | Recombinant Mouse Anti-Human MERTK Antibody (clone B422G0H4) | WB | Mouse antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1725CQ | Recombinant Mouse Anti-MERTK Antibody (NEUT-1725CQ) | BL, WB, IP, IHC-P | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2214 | Hi-Affi™ Recombinant Rabbit Anti-MERTK Monoclonal Antibody (DS2214AB) | WB, IHC, IP, FC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0215-CN | Mouse Anti-MERTK Recombinant Antibody (HPAB-0215-CN) | WB, ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0216-CN | Mouse Anti-MERTK Recombinant Antibody (HPAB-0216-CN) | WB, ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0215-CN-S(P) | Mouse Anti-MERTK Recombinant Antibody; scFv Fragment (HPAB-0215-CN-S(P)) | WB, ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0216-CN-S(P) | Mouse Anti-MERTK Recombinant Antibody; scFv Fragment (HPAB-0216-CN-S(P)) | WB, ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0215-CN-F(E) | Mouse Anti-MERTK Recombinant Antibody; Fab Fragment (HPAB-0215-CN-F(E)) | WB, ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0216-CN-F(E) | Mouse Anti-MERTK Recombinant Antibody; Fab Fragment (HPAB-0216-CN-F(E)) | WB, ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-0988-CN | Recombinant Rabbit Anti-MERTK Monoclonal Antibody (CBACN-367) | WB, IHC, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY31 | Mouse Anti-MERTK scFv-Fc Chimera (VS-0325-FY31) | Inhib | Mouse IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC607 | Recombinant Anti-MERTK Vesicular Antibody, EV Displayed (VS-0425-YC607) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4354 | Anti-Mouse MERTK Immunohistochemistry Kit | IHC |
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