Anti-MITF (clone W24V191) Recombinant Antibody Coupled Liposome (VS-1024-FY192) (CAT#: VS-1024-FY192)
Anti-MITF antibody conjugated liposomes serve as a targeted delivery system for therapies aimed at melanoma, focusing on the microphthalmia-associated transcription factor (MITF). By directing the liposomes to MITF-expressing melanoma cells, they improve drug concentration at the site of action. This strategy enhances efficacy while reducing toxicities associated with systemic treatment. Ultimately, it holds potential for improving patient outcomes in melanoma therapy.
More Infomation
Normal Tissue
RNA Expression
Figure 1 Cervix
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3259/10295_B_7_3_val_selected.jpg
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3259/10295_B_7_3_val_selected.jpg
Figure 2 Colon
(Enterocytes - Mucosal lymphoid cells Staining: Medium Intensity: Strong Quantity: <25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2578/6353_A_9_3.jpg
(Enterocytes - Mucosal lymphoid cells Staining: Medium Intensity: Strong Quantity: <25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2578/6353_A_9_3.jpg
Figure 3 Kidney
(Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3259/10268_A_8_5.jpg
(Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3259/10268_A_8_5.jpg
Figure 4 Skin
(Fibrohistiocytic cells Staining: Low Intensity: Weak Melanocytes Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2578/6353_B_8_1.jpg
(Fibrohistiocytic cells Staining: Low Intensity: Weak Melanocytes Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2578/6353_B_8_1.jpg
Figure 5 Lymph node
(Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2578/6353_A_8_8.jpg
(Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2578/6353_A_8_8.jpg
Figure 6 RNA cell line category: Cell line enhanced (HMC-1, SK-MEL-30)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000187098-MITF
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000187098-MITF
Specifications
- Potential Clinical Applications
- Melanoma
Product Composition
- Clone
- W24V191
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant mouse monoclonal antibody that was specifically engineered to target the Melanocyte Inducing Transcription Factor (MITF). MITF plays a crucial role in the regulation of melanocyte development, function, and survival, making it a significant marker in studies related to pigmentation, melanoma, and other skin-related conditions.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- MITF
- Introduction
- The protein encoded by this gene is a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. The encoded protein regulates melanocyte development and is responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome.
- Alternative Names
- Melanogenesis Associated Transcription Factor; Microphthalmia-Associated Transcription Factor; Class E Basic Helix-Loop-Helix Protein 32; BHLHe32; Microphtalmia-Associated Transcription Factor; Homolog Of Mouse Microphthalmia; Waardenburg Syndrome, Type 2A
- Full Name
- Melanogenesis Associated Transcription Factor
- Gene ID
- 4286
- UniProt ID
- O75030
- Cellular Localization
- Cytoplasm, Nucleus
Downloads
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Antibody Magnetic Beads
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0362MZ | Chicken Anti-MITF Polyclonal IgY | WB | Chicken antibody |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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