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MITF
Anti-MITF Recombinant Antibody Products
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA, FC, ICC, IHC
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- AbPlus™ Anti-MITF Magnetic Beads (C5) (VS-0424-XY187)
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- Target: MITF
- Target Species: Human, Mouse, Rat
- Application: IP, Protein Purification
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- Derivation: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, ICC, FC
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- Mouse Anti-MITF Recombinant Antibody (VS3-CJ169) (VS3-CJ169)
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- Species Reactivity: Human
- Application: IHC
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- Mouse Anti-MITF Recombinant Antibody (VS3-CJ170) (VS3-CJ170)
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- Species Reactivity: Human, Mouse, Rat
- Application: WB
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- Chicken Anti-MITF Polyclonal IgY (BRD-0362MZ)
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- Species Reactivity: Human
- Type: Chicken antibody
- Application: WB
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene is a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. The encoded protein regulates melanocyte development and is responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome.
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Melanocytes, Oligodendrocytes, Oligodendrocyte precursor cells, Inhibitory neurons)
Immune cell specificity
Group enriched (classical monocyte, myeloid DC, non-classical monocyte, basophil, intermediate monocyte)
Cell line specificity
Cell line enhanced (HMC-1, SK-MEL-30)
Interaction
Homodimer or heterodimer; dimerization is mediated via the coiled coil region (PubMed:24631970). Efficient DNA binding requires dimerization with another bHLH protein (PubMed:14975237). Binds DNA in the form of homodimer or heterodimer with either TFE3, TFEB or TFEC (PubMed:15507434). Interacts with KARS1 (PubMed:14975237). Identified in a complex with HINT1 and CTNNB1 (PubMed:22647378). Interacts with VSX2 (By similarity).
Molecular function
Activator, Developmental protein, DNA-binding
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