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MITF
Loading...Anti-MITF Products
- AbPlus™ Anti-MITF Magnetic Beads (C5) (VS-0424-XY187)
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- Target: MITF
- Target Species: Human, Mouse, Rat
- Application: IP, Protein Purification
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA, FC, ICC, IHC
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- Derivation: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, ICC, FC
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- Mouse Anti-MITF Recombinant Antibody (VS3-CJ169) (VS3-CJ169)
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- Species Reactivity: Human
- Application: IHC
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- Mouse Anti-MITF Recombinant Antibody (VS3-CJ170) (VS3-CJ170)
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- Species Reactivity: Human, Mouse, Rat
- Application: WB
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- Chicken Anti-MITF Polyclonal IgY (BRD-0362MZ)
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- Species Reactivity: Human
- Type: Chicken antibody
- Application: WB
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- Derivation: Phage display library screening
- Species Reactivity: Mouse, Rat, Human
- Type: IgG
- Application: WB
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- Mouse Anti-MITF Recombinant Antibody (clone 3A2E2) (VS7-0425-WR385)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: FC
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- Mouse Anti-MITF Recombinant Antibody (clone 8F1G5) (VS7-0425-WR386)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, FC
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- Anti-MITF Immunohistochemistry Kit (VS-0525-XY4402)
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- Species Reactivity: Human
- Target: MITF
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to symmetrical DNA sequences (E-boxes) (5-CACGTG-3) found in the promoters of target genes, such as BCL2 and tyrosinase (TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium.
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Melanocytes, Oligodendrocytes, Oligodendrocyte precursor cells, Inhibitory neurons)
Immune cell specificity
Group enriched (classical monocyte, myeloid DC, non-classical monocyte, basophil, intermediate monocyte)
Cell line specificity
Cell line enhanced (HMC-1, SK-MEL-30)
Interaction
Homodimer or heterodimer; dimerization is mediated via the coiled coil region (PubMed:24631970). Efficient DNA binding requires dimerization with another bHLH protein (PubMed:14975237). Binds DNA in the form of homodimer or heterodimer with either TFE3, TFEB or TFEC (PubMed:15507434). Interacts with KARS1 (PubMed:14975237). Identified in a complex with HINT1 and CTNNB1 (PubMed:22647378). Interacts with VSX2 (By similarity).
Molecular function
Activator, Developmental protein, DNA-binding
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