AibGenesis™ Rabbit Anti-MLLT10 Recombinant Antibody (AibG-Rb-T10257)
CAT#: VS14-YC460
Utilizing deep learning-assisted design, the anti-MLLT10 antibody ensures robust detection of MLLT10 across multiple mammalian species. MLLT10 (also known as AF10) is a critical cofactor for the histone methyltransferase DOT1L. It directs the recruitment of DOT1L to specific gene loci to catalyze the H3K79 methylation mark. This interaction is a central driver of the Wnt/β-catenin signaling pathway and is frequently hijacked in MLL-rearranged leukemias to maintain an aberrant "pro-self-renewal" transcriptional program.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5736/68_F4_2_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5747/69_H4_1_selected.jpg
Normal Tissue
Figure 3 IHC staining of human testis
Immunohistochemical staining of human testis shows strong nuclear positivity in cells in seminiferous ducts.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/72790/171138_A_5_6_selected.jpg
Normal Tissue
Figure 4 High expression in testis
Pachytene spermatocytes Staining: High Intensity: Strong Quantity: 75%-25% Round or early spermatids Staining: High Intensity: Strong Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5747/21104_A_6_6.jpg
RNA Expression
Figure 5 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000078403-MLLT10
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Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- MLLT10
- Species Reactivity
- Human, Mouse, Rat
- Clone
- AibG-Rb-T10257
- Applications
- Western Blot (WB)
Product Property
- Clonality
- Monoclonal
- Purification
- Affinity purified
- Concentration
- 0.3 mg/mL
- Buffer
- 50 mM Tris-Glycine (pH 7.4), 150 mM NaCl, 40% Glycerol and 0.05% BSA
- Preservative
- 0.01% Sodium azide
- Storage
- Store at 4˚C short term. Aliquot and store at -20˚C long term. Avoid freeze/thaw cycles.
Applications
- Application Notes
- Western Blot (WB): 1/1000
Target
- Alternative Names
- MLLT10, Histone Lysine Methyltransferase DOT1L Cofactor; Myeloid/Lymphoid Or Mixed-Lineage Leukemia; Translocated To, 10; ALL1-Fused Gene From Chromosome 10 Protein; AF10; Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax (Drosophila) Homolog); Translocated To, 10; Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila); Translocated To, 10;
- Gene ID
- 8028
- UniProt ID
- P55197
- Long Name
- MLLT10, Histone Lysine Methyltransferase DOT1L Cofactor
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "MLLT10"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0532MZ | Recombinant Mouse Anti-Human MLLT10 Antibody | WB | Mouse antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-FY1641 | Rabbit Anti-MLLT10 Recombinant Antibody (clone R07-2G2) | WB, IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0426-FY577 | AibGenesis™ Rabbit Anti-MLLT10 Recombinant Antibody (AibG-Rb-ML577) | WB, IHC, FC | Rabbit IgG |
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