AibGenesis™ Rabbit Anti-MLLT10 Recombinant Antibody (AibG-Rb-ML577)
CAT#: VS-0426-FY577
Developed through our AI-powered antibody discovery platform, this Rabbit IgG targets MLLT10 (AF10). Validated for WB, IHC, and FC in multiple species, it provides high sensitivity for researchers investigating chromatin-binding proteins and their involvement in chromosomal translocations and the pathogenesis of acute leukemias.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5736/68_F4_2_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5747/69_H4_1_selected.jpg
Normal Tissue
Figure 3 IHC staining of human testis
Immunohistochemical staining of human testis shows strong nuclear positivity in cells in seminiferous ducts.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/72790/171138_A_5_6_selected.jpg
Normal Tissue
Figure 4 High expression in testis
Pachytene spermatocytes Staining: High Intensity: Strong Quantity: 75%-25% Round or early spermatids Staining: High Intensity: Strong Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5747/21104_A_6_6.jpg
RNA Expression
Figure 5 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000078403-MLLT10
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Specifications
- Immunogen
- Human
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human MLLT10
- Species Reactivity
- Human, Mouse, Rat
- Clone
- AibG-Rb-ML577
- Applications
- Western Blot, Immunohistochemistry, Flow Cytometry
- Conjugate
- Unconjugated, Biotin and FITC are available.
- Related Disease
- Acute Myeloid Leukemia (AML)
Product Property
- Clonality
- Monoclonal
- Purification
- Affinity purified
- Format
- Liquid
- Buffer
- 50 mM Tris-Glycine, pH 7.4, 0.15 M NaCl, 40% Glycerol, 0.05% Protective protein
- Preservative
- 0.01% Sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Applications
- Application Notes
- Western Blot (1:500-1:2000), Immunohistochemistry (1:200-1:1000), Flow Cytometry (1:200-1:500)
Target
- Alternative Names
- AF10
- Gene ID
- 8028
- UniProt ID
- P55197
- Long Name
- MLLT10, Histone Lysine Methyltransferase DOT1L Cofactor
- Cellular Localization
- Nucleus
- Post Translation Modifications
- Isopeptide bond, Phosphoprotein, Ubl conjugation
- Protein Refseq
- NP_001182555.1; NP_001182556.1; NP_001182557.1; NP_001182559.1; NP_001311225.1
- Function
- Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation (PubMed:26439302).
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "MLLT10"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0532MZ | Recombinant Mouse Anti-Human MLLT10 Antibody | WB | Mouse antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-FY1641 | Rabbit Anti-MLLT10 Recombinant Antibody (clone R07-2G2) | WB, IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS14-YC460 | AibGenesis™ Rabbit Anti-MLLT10 Recombinant Antibody (AibG-Rb-T10257) | WB | Rabbit IgG |
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