Human Anti-MPO Recombinant Antibody (clone E3-MPO) (CAT#: FAMAB-0256WJ)
Autoantibody
This product is a human monoclonal anti-MPO antibody (E3-MPO) generated using peripheral blood lymphocytes from a patient with microscopic polyarteritis. This antibody can be used in applications, such as ELISA, WB.
Specific Inquiry
Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
ELISA
Figure 1 A syk family kinase and a pertussis sensitive G-protein mediate the effect of E3MPO on neutrophil adhesion.
Preloading of neutrophils with the syk-family kinase inhibitor piceatannol (Pic) (100 nM for 1 h) increased neutrophil binding to plastic in the presence of E3-MPO by over five-fold, neutralizing the inhibitory effect of the antibody.
Hayes, M. J., & Cambridge, G. (2004). An IgM class anti-neutrophil cytoplasm antibody inhibits neutrophil adhesion and apoptosis via a Syk dependent signaling cascade. Molecular immunology, 41(4), 457–468.
IF
Figure 1 Indirect Immunofluorescence of MPO
Indirect Immunofluorescence of MPO A and D (stained with E3-MPO) and CD18 B and E reveals co-localization on the surface of freshlypurified neutrophils C and F.
Hayes, M. J., & Cambridge, G. (2004). An IgM class anti-neutrophil cytoplasm antibody inhibits neutrophil adhesion and apoptosis via a Syk dependent signaling cascade. Molecular immunology, 41(4), 457–468.
Specifications
- Host Species
- Human
- Derivation
- Hybridoma
- Type
- Human IgG
- Specificity
- Myeloperoxidase
- Species Reactivity
- Human
- Clone
- E3-MPO
- Applications
- ELISA, WB
- Related Disease
- vasculitis
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| DrMAB-1015 | Recombinant Mouse Anti-Human MPO Antibody Fab Fragment | LMNX, ELISA | Fab |
| FAMAB-0256WJ-F(E) | Human Anti-MPO Recombinant Antibody (clone E3-MPO); Fab Fragment | ELISA, WB | Human Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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