Mouse Anti-MSH2 Monoclonal Antibody (VS7-0425-WR419)
CAT#: VS7-0425-WR419
This product is a mouse IgG antibody that binds to human MSH2. The antibody can be used for WB, IHC-P, IF, ICC, and ELISA assays. It cross reacts with monkey.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line RH-30
Immunofluorescent staining of human cell line RH-30 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/66845/1768_C3_11_cr594bb51d24b1e_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/9572/if_selected.jpg
Normal Tissue
Figure 3 Lymph node
Germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: nuclear Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/9572/26473_A_9_8.jpg
Normal Tissue
Figure 4 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/9572/26473_A_8_3.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/9572/26473_A_7_5.jpg
RNA Expression
Figure 6 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000095002-MSH2
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Specifications
- Immunogen
- Recombinant human MSH2 fragment expressed in E. Coli.
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human MSH2
- Species Reactivity
- Human, Monkey
- Molecule Class
- Muts Complex
- Applications
- WB, IHC-P, IF, ICC, ELISA
- Conjugate
- Unconjugated
- Related Disease
- Lynch syndrome 1 (LYNCH1); Muir-Torre syndrome (MRTES); Endometrial cancer (ENDMC); Mismatch repair cancer syndrome 2 (MMRCS2); Colorectal cancer (CRC)
Product Property
- Clonality
- Monoclonal
- Purity
- >95% as determined by SDS-PAGE and SEC-HPLC analysis, Ascitic fluid
- Format
- Liquid
- Concentration
- 1 mg/ml
- Preservative
- 0.03% sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Aliquot and store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Western Blot: 1:500 - 1:2000
Immunohistochemistry: 1:200 - 1:1000
Immunofluorescence: 1:200 - 1:1000
Enzyme-linked Immunosorbent Assay: 1:10000
Target
- Alternative Names
- MSH2; HNPCC; MutS Protein Homolog 2; MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli); HMSH2; MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1; MutS (E. Coli) Homolog 2 (Colon Cancer, Nonpolyposis Type 1); DNA Mismatch Repair Protein Msh2; HNP
- Gene ID
- 4436
- UniProt ID
- P43246
- Long Name
- MutS Homolog 2
- Cellular Localization
- Chromosome; Nucleus
- Post Translation Modifications
- Acetylation; Isopeptide bond; Phosphoprotein; Ubl conjugation
- Protein Refseq
- NP_000242.1
- Function
- DNA-binding
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "MSH2"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0922MZ | Recombinant Mouse Anti-Human MSH2 Antibody (clone 36E23) | IHC-Fr, WB | Mouse antibody |
| ZG-0289C | Mouse Anti-MSH2 Recombinant Antibody (ZG-0289C) | WB, IHC, IF, ELISA | Mouse IgG |
| ZG-0369U | Rabbit Anti-MSH2 Recombinant Antibody (clone N29-D) | IHC-P | Rabbit IgG |
| VS7-0425-WR417 | Mouse Anti-MSH2 Recombinant Antibody (clone 4F10D6) | FC | Mouse IgG2b |
| VS7-0425-WR418 | Mouse Anti-MSH2 Monoclonal Antibody (clone 1B3A8A8) | WB, IHC, ICC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2297 | Hi-Affi™ Recombinant Rabbit Anti-MSH2 Monoclonal Antibody (DS2297AB) | FC, ICC, IF, IHC-P, WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC845 | AbPlus™ Anti-MSH2 Magnetic Beads (VS-0724-YC845) | IP, Protein Purification |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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