Anti-MST1R Antibody Prodrug, Protease Activated (MOR07923)
CAT#: VS-1025-YC92
The Anti-MST1R Antibody Prodrug, Protease Activated (MOR07923) is an antibody prodrug comprised of a recombinant human antibody targeting human and Monkey MST1R, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to MST1R protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to MST1R effectively. MST1R, also known as RON (Recepteur d'Origine Nantaise), is a receptor tyrosine kinase related to MET that is often overexpressed or constitutively activated in many epithelial cancers, including breast and colon. Its signaling promotes cell scattering, invasion, and metastasis. Inhibitors targeting this receptor are under investigation to block tumor spread.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/44_E6_1_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/22751_B_8_5.jpg
Normal Tissue
Figure 3 Colon
Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/22751_A_7_3.jpg
Normal Tissue
Figure 4 Liver
Cholangiocytes Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/22751_A_7_4.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/22751_A_9_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/22751_A_6_6.jpg
Normal Tissue
Figure 7 Skin
Fibroblasts Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Keratinocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Melanocytes Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/22751_B_8_1.jpg
Normal Tissue
Figure 8 Lymph node
Germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/22751_A_8_8.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced (A-431, CAPAN-2, HaCaT, HBEC3-KT, hTCEpi, RT4)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000164078-MST1R
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Specifications
- Host Animal
- Human
- Applications
- In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay
- Specificity
- Human and Monkey MST1R
- Target
- MST1R
- Species Reactivity
- Human, Monkey
- Isotype
- IgG
- Clone
- MOR07923
- Masking Approach
- Affinity mask
- Mask
- A synthetic peptide
- Protease Cleavable Linker
- MMP-cleavable linker
- Protease Substrate
- MMPs
- Purification
- Protein A purified
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Target
- Introduction
- This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and together with MSP, thought to be involved in host defense. Alternatively spliced transcript variants encoding different isoforms with different structural and biochemical properties have been described (PMID:8816464).
- Alternative Names
- MST1R; macrophage stimulating 1 receptor (c-met-related tyrosine kinase); RON; PTK8; CD136; CDw136
- Gene ID
- 4486
- UniProt ID
- Q04912
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3123z | Mouse Anti-MST1R Recombinant Antibody (clone 29B12) | WB, IP, IF, ELISA | Mouse IgG1, κ |
| MOB-1279MZ | Recombinant Mouse Anti-Human MST1R Antibody (clone 2C6B0) | ELISA, WB | Mouse antibody |
| HPAB-0062-CN | Human Anti-MST1R Recombinant Antibody (clone MOR07923) | IP, ELISA, FC | Human IgG |
| HPAB-0063-CN | Human Anti-MST1R Recombinant Antibody (clone MOR07924) | IP, ELISA, FC | Human IgG |
| HPAB-0064-CN | Human Anti-MST1R Recombinant Antibody (clone MOR07925) | IP, ELISA, FC | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-184 | Anti-Human RON Recombinant Antibody (Narnatumab) | FuncS, IF, Neut, ELISA, FC, IP, ICC | IgG1 - kappa |
| TAB-332CT | Anti-Human RON Recombinant Antibody (TAB-332CT) | WB, ELISA, FC | Human antibody |
| TAB-333CT | Human Anti-MST1R Recombinant Antibody (TAB-333CT) | WB, ELISA, FC, IP | Human IgG |
| TAB-332CT-S(P) | Anti-Human RON Recombinant Antibody scFv Fragment (TAB-332CT-S(P)) | WB, ELISA, FC | Human antibody |
| TAB-333CT-S(P) | Human Anti-MST1R Recombinant Antibody; scFv Fragment (TAB-333CT-S(P)) | WB, ELISA, FC, IP | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-331CT | Anti-Human RON Recombinant Antibody (TAB-331CT) | WB, ELISA, FC | |
| TAB-334CT | Mouse Anti-MST1R Recombinant Antibody (TAB-334CT) | WB, ELISA, FC, IP | Mouse IgG2a, κ |
| TAB-335CT | Mouse Anti-MST1R Recombinant Antibody (TAB-335CT) | WB, ELISA, FC, IP | Mouse IgG2a, κ |
| TAB-331CT-S(P) | Anti-Human RON Recombinant Antibody scFv Fragment (TAB-331CT-S(P)) | WB, ELISA, FC | |
| TAB-334CT-S(P) | Mouse Anti-MST1R Recombinant Antibody; scFv Fragment (TAB-334CT-S(P)) | WB, ELISA, FC, IP | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1756CQ | Recombinant Mouse Anti-MST1R Antibody (CBL312) | BL | IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1757CQ | Recombinant Mouse Anti-MST1R Antibody (MM0478-10F24) | Neut | IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2309 | Hi-Affi™ Recombinant Rabbit Anti-MST1R Monoclonal Antibody (DS2309AB) | FC, ICC, IF, IHC-P, IP, WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0062-CN-S(P) | Human Anti-MST1R Recombinant Antibody (clone MOR07923); scFv Fragment | IP, ELISA, FC | Human scFv |
| HPAB-0063-CN-S(P) | Human Anti-MST1R Recombinant Antibody (clone MOR07924); scFv Fragment | IP, ELISA, FC | Human scFv |
| HPAB-0064-CN-S(P) | Human Anti-MST1R Recombinant Antibody (clone MOR07925); scFv Fragment | IP, ELISA, FC | Human scFv |
| HPAB-0135-FY-S(P) | Human Anti-MST1R Recombinant Antibody (clone sh29B06-78); scFv Fragment | WB | Humanized scFv |
| HPAB-0821-CN-S(P) | Human Anti-MST1R Recombinant Antibody (clone MOR07692); scFv Fragment | WB, ELISA, FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0062-CN-F(E) | Human Anti-MST1R Recombinant Antibody (clone MOR07923); Fab Fragment | IP, ELISA, FC | Human Fab |
| HPAB-0063-CN-F(E) | Human Anti-MST1R Recombinant Antibody (clone MOR07924); Fab Fragment | IP, ELISA, FC | Human Fab |
| HPAB-0064-CN-F(E) | Human Anti-MST1R Recombinant Antibody (clone MOR07925); Fab Fragment | IP, ELISA, FC | Human Fab |
| HPAB-0135-FY-F(E) | Human Anti-MST1R Recombinant Antibody (clone sh29B06-78); Fab Fragment | WB | Humanized Fab |
| HPAB-0821-CN-F(E) | Human Anti-MST1R Recombinant Antibody (clone MOR07692); Fab Fragment | WB, ELISA, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-184 | Afuco™ Anti-MST1R ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-184) | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY190 | AbPlus™ Anti-MST1R Magnetic Beads (MOR07923) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY152 | Human Anti-MST1R (clone M93-D02) scFv-Fc Chimera | WB, ELISA, FC, IP | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC486 | Recombinant Anti-MST1R Vesicular Antibody, EV Displayed (VS-0425-YC486) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4549 | Anti-MST1R Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0825-YC259 | SmartAb™ Recombinant Anti-MST1R pH-dependent Antibody (Clone Narnatumab) | IF, Neut, ELISA, FC, IP, ICC | Human IgG1 kappa |
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