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    MST1R

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    Anti-MST1R Products

    • Anti-RON (clone Zt/g4)-SMCC-DM1 ADC (ADC-228LZY)
      • Target: RON
      • Linker: SMCC (4-[N-maleimidomethyl] cyclohexane-1 carboxylhydrazide).
      • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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    • Anti-RON (clone Zt/c1)-SMCC-DM1 ADC (ADC-229LZY)
      • Target: RON
      • Linker: SMCC (4-[N-maleimidomethyl] cyclohexane-1 carboxylhydrazide).
      • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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    For Research Use Only. Not For Clinical Use.


    Background

    This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and together with MSP, thought to be involved in host defense. Alternatively spliced transcript variants encoding different isoforms with different structural and biochemical properties have been described (PMID:8816464).
    MST1R
    Protein class

    CD markers, Disease related genes, Enzymes, Metabolic proteins, Potential drug targets

    Predicted location

    Intracellular, Membrane (different isoforms)

    Single cell type specificity

    Cell type enhanced (Gastric mucus-secreting cells, Distal enterocytes, Pancreatic endocrine cells, Paneth cells, Proximal enterocytes, Intestinal goblet cells, Alveolar cells type 1)

    Immune cell specificity

    Not detected in immune cells

    Cell line specificity

    Cell line enhanced (A-431, CAPAN-2, HaCaT, HBEC3-KT, hTCEpi, RT4)

    Interaction

    Heterodimer of an alpha chain and a beta chain which are disulfide linked. Binds PLXNB1. Associates with and is negatively regulated by HYAL2. Interacts when phosphorylated with downstream effectors including PIK3R1, PCLG1, GRB2 and GAB1. Interacts with integrin beta1/ITGB1 in a ligand-independent fashion.

    Molecular function

    Kinase, Receptor, Transferase, Tyrosine-protein kinase

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