Recombinant Human Anti-N. meningitidis fHbp Antibody (1A12)
CAT#: PABC-429
This product is a recombinant Human antibody that can recognize N. meningitidis fHbp. mAb 1A12 binds to all three tested MenB strains expressing fHbp from different variant groups: strains H44/76 (fHbp var1.1); M08-0240104 (fHbp var2.16); and M01-0240320 (fHbp var3.45).
Published Data
SPR
Figure 1 SPR binding competition analysis of cooperative and noncooperative fHbp-mAb complexes.
The first SPR signal in plot corresponds to the capturing of fHbp by the mAb coupled to the chip surface. The injection of the second mAb only produces an additional signal if cooperative couples are formed. Sensograms were normalized to the fHbp capture level to compensate for differences in capture.efficiency on different mAbs. The color code of the second mAb is reported in the legend.
Peschiera, I., Giuliani, M., Giusti, F., Melero, R., Paccagnini, E., Donnarumma, D., ... & Masignani, V. (2019). Structural basis for cooperativity of human monoclonal antibodies to meningococcal factor H-binding protein. Communications biology, 2.
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Specifications
- Immunogen
- A MenB vaccine formulation that contained fHbp var1.1
- Host Species
- Human
- Type
- Human IgG1
- Specificity
- N. meningitidis fHbp
- Species Reactivity
- N. meningitidis serogroup B (MenB)
- Clone
- 1A12
- Applications
- SPR, ELISA, FC
Product Property
- Purity
- >95% as determined by analysis by SDS-PAGE
- Storage
- Store at -20°C for long-term storage. Avoid freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been tested for use in Enzyme-linked Immunosorbent Assay, Surface Plasmon Resonance and Flow Cytometry. It's recommended that the optimal antibody concentration, dilution, incubition time, etc. be carefully titrated in specific assays.
Target
- Alternative Names
- Neisseria meningitidis factor H-binding protein; Neisseria meningitidis factor H-binding protein
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone 1A12"
- CAT
- Product Name
See other products for "N. meningitidis fHbp"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBC-429 | Recombinant Human Anti-N. meningitidis fHbp Antibody Fab Fragment (1A12) | ELISA, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBC-429 | Recombinant Human Anti-N. meningitidis fHbp Antibody scFv Fragment (1A12) | ELISA, FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0723-CJ32 | Human Anti-N. meningitidis fHbp Recombinant Antibody (clone 1A3) | ELISA, SPR | Human IgG |
| VS-0724-FY11 | Human Anti-N. meningitidis fHbp Recombinant Antibody (clone 4B3) | FC, Inhib | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY3 | Human Anti-N. meningitidis fHbp scFv-Fc Chimera (VS-0125-FY3) | IA | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1224-YC1742 | DrugMonitor™ Anti-N. meningitidis fhbp Antibody (VS-1224-YC1742) | ELISA, PK/PD, ADA control | Mouse IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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