Recombinant Human Anti-N. meningitidis fHbp Antibody (1A12) (CAT#: PABC-429)
This product is a recombinant Human antibody that can recognize N. meningitidis fHbp. mAb 1A12 binds to all three tested MenB strains expressing fHbp from different variant groups: strains H44/76 (fHbp var1.1); M08-0240104 (fHbp var2.16); and M01-0240320 (fHbp var3.45).
Specific Inquiry
SPR
Figure 1 SPR binding competition analysis of cooperative and noncooperative fHbp-mAb complexes.
The first SPR signal in plot corresponds to the capturing of fHbp by the mAb coupled to the chip surface. The injection of the second mAb only produces an additional signal if cooperative couples are formed. Sensograms were normalized to the fHbp capture level to compensate for differences in capture.efficiency on different mAbs. The color code of the second mAb is reported in the legend.
Peschiera, I., Giuliani, M., Giusti, F., Melero, R., Paccagnini, E., Donnarumma, D., ... & Masignani, V. (2019). Structural basis for cooperativity of human monoclonal antibodies to meningococcal factor H-binding protein. Communications biology, 2.
Specifications
- Immunogen
- A MenB vaccine formulation that contained fHbp var1.1
- Host Species
- Human
- Type
- Human IgG1
- Specificity
- N. meningitidis fHbp
- Species Reactivity
- N. meningitidis serogroup B (MenB)
- Clone
- 1A12
- Applications
- SPR, ELISA, FC
Product Property
- Purity
- >95% as determined by analysis by SDS-PAGE
- Storage
- Store at -20°C for long-term storage. Avoid freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been tested for use in Enzyme-linked Immunosorbent Assay, Surface Plasmon Resonance and Flow Cytometry. It's recommended that the optimal antibody concentration, dilution, incubition time, etc. be carefully titrated in specific assays.
Target
- Alternative Names
- Neisseria meningitidis factor H-binding protein; Neisseria meningitidis factor H-binding protein
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBC-429 | Recombinant Human Anti-N. meningitidis fHbp Antibody Fab Fragment (1A12) | ELISA, FC | Human Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBC-429 | Recombinant Human Anti-N. meningitidis fHbp Antibody scFv Fragment (1A12) | ELISA, FC | Human scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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