Recombinant Anti-N. meningitidis porA (P1.7 epitope x P1.16 epitope) Biparatopic Antibody, Tandem scFv (Clone 208,D-5 x Clone 151,F-9) (CAT#: VS-0525-YC135)

• Host Animal 1
• Human

• Host Animal 2
• Mouse

• Specificity
• Neisseria meningitidis PorA

• Species Reactivity
• N. meningitidis

• Type
• Tandem scFv

• Valency
• 1 + 1

• Clone 1
• 208,D-5

• Clone 2
• 151,F-9

• Epitope 1
• P1.7 epitope of PorA

• Epitope 2
• P1.16 epitope of PorA

• Purity
• >90%

• Purification
• Affinity purified

• Applications
• ELISA, FC

• Concentration
• Lot specific

• Buffer
• PBS, pH 7.4

• Preservative
• No preservatives

• Storage
• Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.

• Long Name
• N. meningitidis outer membrane protein porA

• Introduction
• The class 1 outer membrane porin protein, PorA, is expressed by almost all meningococcal strains, and antigenic variation among PorA proteins is the basis of serosubtyping. PorA can induce bactericidal anti- bodies in humans and mice when they are immunized with meningococcal outer membrane vesicles (OMVs), and monoclonal antibodies (MAbs) against PorA can be protective in an infant rat model. Thus, the PorA protein is considered to be an important vaccine antigen and is therefore the main component in a Dutch candidate vaccine.

• Alternative Names
• Outer membrane protein PorA; PorA

• Gene ID
• 903851

• UniProt ID
• P0DH58

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