Anti-NEFL (clone MS-B1) Recombinant Antibody Coupled Liposome (VS-1024-FY116)
CAT#: VS-1024-FY116
Neurofilament light chain (NEFL) antibody-conjugated liposomes have been developed for targeted therapy in gliomas. Studies have shown that this liposomal system can effectively and selectively target glioma cells, potentially enhancing drug therapeutic effects and improving survival rates. Related research indicates that functionalized liposomes can optimize drug delivery for gliomas.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HEK 293
Immunofluorescent staining of human cell line HEK 293 shows localization to nucleoplasm, intermediate filaments & midbody.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/15021/1910_D3_1_selected.jpg
Normal Tissue
Figure 2 Low expression in tonsil
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14850/165171_A_6_8_val_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuropil Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14850/165171_B_8_5.jpg
RNA Expression
Figure 4 RNA cell line category: Group enriched (HEK93, PC-3)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000277586-NEFL
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More Infomation
Specifications
- Potential Clinical Applications
- Glioma
Product Composition
- Clone
- MS-B1
- Antibody Type
- IgG
- Antibody Host
- Human
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant human monoclonal antibody that has been meticulously engineered to specifically target and bind to the human neurofilament light chain (NEFL). Neurofilament light chain is a key protein found in the neurons of the central and peripheral nervous systems, serving as an essential component of the cytoskeleton that maintains neuronal structure and integrity.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- NEFL
- Introduction
- Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y.
- Alternative Names
- Neurofilament Light; Protein Phosphatase 1, Regulatory Subunit 110; Neurofilament, Light Polypeptide 68kDa; Neurofilament Triplet L Protein; NF-L; NF68; NFL; Light Molecular Weight Neurofilament Protein; Neurofilament Protein, Light Chain
- Full Name
- Neurofilament Light
- Gene ID
- 4747
- UniProt ID
- P07196
- Sequence Similarities
- Belongs to the intermediate filament family.
- Cellular Localization
- Cell projection, Cytoplasm, Cytoskeleton, Intermediate filament
- Post Translation Modifications
- O-glycosylated.
Phosphorylated in the head and rod regions by the PKC kinase PKN1, leading to the inhibition of polymerization.
Ubiquitinated in the presence of TRIM2 and UBE2D1.
- Protein Refseq
- NP_006149.2
- Function
- Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity).
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone MS-B1"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2006z | Mouse Anti-NEFL Recombinant Antibody (clone 32C12) | WB, ELISA, FC, ICC, IF, IHC | Mouse IgG1 |
| VS3-XY1150 | Mouse Anti-NEFL Recombinant Antibody (clone 2G10) | ELISA, WB, IHC, FC, ICC | Mouse IgG1 |
| VS3-FY1025 | Recombinant Rabbit Anti-Nefl Antibody (clone R04-7H3) | WB, IHC-P, IP | Rabbit IgG |
| VS3-FY1026 | Recombinant Mouse Anti-NEFL Antibody (clone 2D7-6C10-10B2) | IHC-P | Mouse IgG2b |
| VS7-0425-WR462 | Mouse Anti-NEFL Recombinant Antibody (clone 2F8B3) | WB, IHC, FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0822MZ | Chicken Anti-NEFL Polyclonal IgY | ICC, IF, IHC, WB | Chicken antibody |
| BRD-1153MZ | Chicken Anti-Neurofilament Light Polyclonal IgY | WB, ICC | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2411 | Hi-Affi™ Recombinant Rabbit Anti-NEFL Monoclonal Antibody (DS2411AB) | WB, IP, FC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS13-YC782 | CytoStream™ Mouse Anti-NEFL Recombinant Antibody (VS13-YC782) | WB, IHC-P, FC, ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4777 | Anti-NEFL Immunohistochemistry Kit | IHC | |
| VS-0525-XY4778 | Anti-Mouse NEFL Immunohistochemistry Kit | IHC | |
| VS-0525-XY4780 | Anti-Rat NEFL Immunohistochemistry Kit | IHC |
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