Anti-NEFL (clone MS-B1) Recombinant Antibody Coupled Liposome (VS-1024-FY116) (CAT#: VS-1024-FY116)

• Potential Clinical Applications
• Glioma

• Clone
• MS-B1

• Antibody Type
• IgG

• Antibody Host
• Human

• Antibody Reactivity
• Human

• Antibody Description
• This is a recombinant human monoclonal antibody that has been meticulously engineered to specifically target and bind to the human neurofilament light chain (NEFL). Neurofilament light chain is a key protein found in the neurons of the central and peripheral nervous systems, serving as an essential component of the cytoskeleton that maintains neuronal structure and integrity.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• NEFL

• Introduction
• Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y.

• Alternative Names
• Neurofilament Light; Protein Phosphatase 1, Regulatory Subunit 110; Neurofilament, Light Polypeptide 68kDa; Neurofilament Triplet L Protein; NF-L; NF68; NFL; Light Molecular Weight Neurofilament Protein; Neurofilament Protein, Light Chain

• Full Name
• Neurofilament Light

• Gene ID
• 4747

• UniProt ID
• P07196

• Sequence Similarities
• Belongs to the intermediate filament family.

• Cellular Localization
• Cell projection, Cytoplasm, Cytoskeleton, Intermediate filament

• Post Translation Modifications
• O-glycosylated.
  Phosphorylated in the head and rod regions by the PKC kinase PKN1, leading to the inhibition of polymerization.
  Ubiquitinated in the presence of TRIM2 and UBE2D1.

• Protein Refseq
• NP_006149.2

• Function
• Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity).

• FAMAB-0007WJ-mRNA
• Human Anti-NEFL Antibody (clone MS-B1), mRNA

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