Rabbit Anti-NKX2-1 Recombinant Antibody (VS13-YC811) (CAT#: VS13-YC811)
The Rabbit Anti-NKX2-1 Recombinant Antibody is specific for human and hamster NKX2-1. NKX2-1 is a thyroid-specific transcription factor regulating thyroid genes and morphogenesis-related genes. Mutations associate with diseases like benign hereditary chorea and cancers. It has multiple transcript variants. The anti-NKX2-1 antibody can be used for Western blot (1/500-1/1000), Immunofluorescence (1/50-1/200).
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line HEK 293
(Immunofluorescent staining of human cell line HEK 293 shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/74316/1569_C4_3_selected.jpg
(Immunofluorescent staining of human cell line HEK 293 shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/74316/1569_C4_3_selected.jpg
Figure 2 Thyroid gland
(Glandular cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/53633/117834_B_3_5.jpg
(Glandular cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/53633/117834_B_3_5.jpg
Figure 3 RNA cell line category: Cell line enriched (SCLC-21H)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000136352-NKX2-1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000136352-NKX2-1
Figure 3 RNA cell line category: Cell line enriched (SCLC-21H)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000136352-NKX2-1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000136352-NKX2-1
Specifications
- Immunogen
- Recombinant human TTF1.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human and Hamster NKX2-1
- Species Reactivity
- Human, Hamster
- Applications
- WB, ICC, IF
- Conjugate
- NONE
- Related Disease
- Cancer
Product Property
- Clonality
- Monoclonal
- Purification
- Affinity Chromatography purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- 50 mM Tris-Glycine (pH 7.4) containing 150 mM NaCl, 40% Glycerol and 0.05% BSA.
- Preservative
- 0.01% Sodium azide
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Western blot (WB): 1/500-1/1000
Immunofluorescence (IF): 1/50-1/200
Target
- Alternative Names
- NK2 Homeobox 1; Thyroid Transcription Factor 1; Thyroid-Specific Enhancer-Binding Protein; Homeobox Protein NK-2 Homolog A; Thyroid Nuclear Factor 1; NKX2A; TITF1; T/EBP; TTF-1; TTF1;
- Gene ID
- 7080
- UniProt ID
- P43699
- Long Name
- NK2 Homeobox 1
- Sequence Similarities
- Belongs to the NK-2 homeobox family.
- Cellular Localization
- Nucleus
- Protein Refseq
- NP_001073136.1; NP_003308.1
- Function
- May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression.
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "NKX2-1"
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IgG Antibody Products
Rabbit Monoclonal Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1310z | Mouse Anti-NKX2-1 Recombinant Antibody (clone 11B10) | IF, IHC, WB | Mouse IgG2b |
| MOB-0342MZ | Recombinant Mouse Anti-Human NK2 Homeobox 1 Antibody (clone 9H8G4/2) | IHC | Mouse antibody |
| ZG-0122C | Mouse Anti-NKX2-1 Recombinant Antibody (clone ABT-TTF1) | IHC-P, IF | Mouse IgG |
| ZG-0123C | Mouse Anti-NKX2-1 Recombinant Antibody (clone PT2256) | IHC-P, IF | Mouse IgG |
| VS3-XY3446 | Rabbit Anti-NKX2-1 Recombinant Antibody (clone R07-3I9) | WB, IHC-P, ICC, IF, FC | Rabbit IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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