Anti-NME2 (clone W24V196) Recombinant Antibody Coupled Liposome (VS-1024-FY195)
CAT#: VS-1024-FY195
Anti-PD-1 antibody conjugated liposomes hold significant potential in the treatment of Adrenocortical carcinoma by enhancing the immune response against tumor cells. By targeting the PD-1 immune checkpoint pathway, these liposomes could improve T-cell activation and promote antitumor immunity, potentially leading to better patient outcomes. Additionally, the liposomal delivery system can enhance the bioavailability and stability of the conjugated antibodies, ensuring sustained therapeutic effects at the tumor site. Overall, this innovative approach may pave the way for more effective immunotherapies in combating Adrenocortical carcinoma and other malignancies.
Anti-PD-1 antibody conjugated liposomes hold promise in metastatic fibrosarcoma research by enhancing the immune response against tumor cells and improving therapeutic efficacy. By delivering the antibody directly to the tumor microenvironment, these liposomes can potentially reduce systemic side effects while increasing local drug concentration. Furthermore, this targeted approach may lead to synergistic effects when combined with other treatments, thereby improving overall patient outcomes in advanced cancer stages.



Specifications
- Potential Clinical Applications
- Adrenocortical carcinoma, Metastatic fbrosarcoma
Product Composition
- Clone
- W24V196
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This recombinant mouse monoclonal antibody has been specifically engineered to bind with precision to the NME2 protein. By harnessing the power of monoclonal antibody technology, researchers can investigate the biochemical pathways in which NME2 is involved, contributing valuable insights into cellular mechanisms. The unique binding properties of this antibody make it a useful tool for both diagnostic and therapeutic applications, particularly in understanding diseases where NME2 has been implicated.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- NME2
- Introduction
- Nucleoside diphosphate kinase (NDK) exists as a hexamer coNME2sed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants have been found for this gene. Read-through transcription from the neighboring upstream gene (NME1) generates naturally-occurring transcripts (NME1-NME2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product.
- Alternative Names
- NME/NM23 Nucleoside Diphosphate Kinase 2; Non-Metastatic Cells 2, Protein (NM23B) Expressed In; C-Myc Purine-Binding Transcription Factor PUF; Histidine Protein Kinase NDKB; NDP Kinase B; EC 2.7.4.6;6 NM23-H2; NM23B; Epididymis Secretory Sperm Binding Protein Li 155an; Non-Metastatic Cells 2, Protein (NM23) Expressed In; Nucleoside Diphosphate Kinase B
- Full Name
- NME/NM23 Nucleoside Diphosphate Kinase 2
- Gene ID
- 4831
- UniProt ID
- P22392
- Sequence Similarities
- Belongs to the NDK family.
- Cellular Localization
- Cell projection, Cytoplasm, Nucleus
- Positive Control
- The positive control samples for this antibody include Mouse spleen lysates.
- Post Translation Modifications
- Ubiquitination at Lys39 and Lys128 (NX_P22392 [NX_P22392-1])
Modification sites at PhosphoSitePlus (P22392)
Glycosylation from GlyGen (P22392) 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- NP_001018147.1; NP_001018148.1; NP_001018149.1; NP_001185611.1; NP_002503.1
- Function
- Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752, PubMed:19435876).
Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III1 region of the MYC gene promoter. Does not bind to duplex NHE III1.
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Downloadable Resources
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Datasheet
MSDS
COA
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See other products for "NME2"
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CAT | Product Name | Application | Type |
---|---|---|---|
MOB-3844z | Mouse Anti-NME2 Recombinant Antibody (clone 42H8) | WB, IP, ELISA | Mouse IgG1, κ |
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CAT | Product Name | Application | Type |
---|---|---|---|
MOR-2457 | Hi-Affi™ Recombinant Rabbit Anti-NME2 Monoclonal Antibody (DS2457AB) | WB, IHC, ICC, FC | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
VS13-YC819 | CytoStream™ Rabbit Anti-NME2 Recombinant Antibody (VS13-YC819) | WB, IHC, IF, FC | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0525-XY4875 | Anti-NME2 Immunohistochemistry Kit | IHC | |
VS-0525-XY4876 | Anti-Mouse NME2 Immunohistochemistry Kit | IHC |
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