AibGenesis™ Rabbit Anti-NRG3 Recombinant Antibody (AibG-Rb-NR623)
CAT#: VS-0426-FY623
Produced by our AI-powered discovery platform, this antibody targets NRG3. It is affinity purified and validated for WB and Flow Cytometry in mammalian models.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/75789/1672_E7_32_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Cell line enhanced (HEK93, SK-MEL-30, U-2 OS)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000185737-NRG3
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Specifications
- Immunogen
- Human
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human NRG3
- Species Reactivity
- Human, Mouse, Rat
- Clone
- AibG-Rb-NR623
- Applications
- Western Blot, Flow Cytometry
- Conjugate
- Unconjugated, Biotin and FITC are available.
- Related Disease
- Hirschsprung Disease
Product Property
- Clonality
- Monoclonal
- Purification
- Affinity purified
- Format
- Liquid
- Buffer
- PBS, 0.05% Protective protein, 50% Glycerol
- Preservative
- 0.05% Sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Applications
- Application Notes
- Western Blot (1:1000-1:2000), Flow Cytometry (1:20-1:100)
Target
- Alternative Names
- HRG3; Neuregulin 3; Nrg3; Pro neuregulin 3; NRG3
- UniProt ID
- P56975
- Long Name
- Neuregulin 3
- Sequence Similarities
- Belongs to the neuregulin family.
- Cellular Localization
- Cell membrane, Membrane, Secreted
- Post Translation Modifications
- Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form. (P56975-NRG3_HUMAN)
Extensive glycosylation precedes the proteolytic cleavage.
Isoform 3 is glycosylated.
Glycosylation at Thr276, Thr277, Thr278, Ser280, and Thr281 (NX_P56975 [NX_P56975-1])
Modification sites at PhosphoSitePlus (P56975)
Glycosylation from GlyGen (P56975) 6 sites, 1 O-linked glycan (6 sites)
- Protein Refseq
- XP_011537474.1; XP_011537475.1; XP_011537477.1; XP_011537480.1; XP_016871062.1
- Function
- Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes.
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Related Signaling Pathways
ErbB Signaling Pathway
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "NRG3"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2500 | Hi-Affi™ Recombinant Rabbit Anti-NRG3 Monoclonal Antibody (DS2500AB) | WB, FC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-FY1802 | Rabbit Anti-NRG3 Recombinant Antibody (clone R02-9E5) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS14-YC480 | AibGenesis™ Rabbit Anti-NRG3 Recombinant Antibody (AibG-Rb-RG277) | WB | Rabbit IgG |
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