Mouse Anti-PBRM1 Recombinant Antibody (VS3-FY2830) (CAT#: VS3-FY2830)
This anti-PBRM1 antibody is a mouse recombinant monoclonal antibody that has been specifically designed to target the human, mouse PBRM1 protein, a calculated molecular weight of the protein is about 192.9 kDa. This monoclonal antibody proves valuable in disease research related to Renal Cell Carcinoma, Nonpapillary, Clear Cell Papillary Renal Cell Carcinoma.
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Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line RT4
(Immunofluorescent staining of human cell line RT4 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/15629/1395_H9_1_selected.jpg
(Immunofluorescent staining of human cell line RT4 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/15629/1395_H9_1_selected.jpg
Figure 2 IHC staining of human cerebral cortex
(Immunohistochemical staining of human cerebral cortex shows strong nuclear positivity in neuronal cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/15629/ihc_selected.jpg
(Immunohistochemical staining of human cerebral cortex shows strong nuclear positivity in neuronal cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/15629/ihc_selected.jpg
Figure 3 Cerebral cortex
(Neuronal cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/15629/34465_B_7_5.jpg
(Neuronal cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/15629/34465_B_7_5.jpg
Figure 4 Colon
(Glandular cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/15629/34414_A_8_3.jpg
(Glandular cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/15629/34414_A_8_3.jpg
Figure 5 Testis
(Cells in seminiferous ducts
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Nuclear
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/15629/34414_A_4_6.jpg
(Cells in seminiferous ducts
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Nuclear
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/15629/34414_A_4_6.jpg
Figure 6 Lymph node
(Non-germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/15629/34414_A_9_8.jpg
(Non-germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/15629/34414_A_9_8.jpg
Figure 7 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000163939-PBRM1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000163939-PBRM1
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human and Mouse PBRM1
- Species Reactivity
- Human, Mouse
- Applications
- Western Blot
- Conjugate
- Unconjugated, FITC
- MW
- The molecular weight of the target protein is approximately 192.9 kDa.
- Related Disease
- Renal Cell Carcinoma; Nonpapillary; Clear Cell Papillary Renal Cell Carcinoma
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Target
- Alternative Names
- Polybromo 1; BRG1-Associated Factor 180; Polybromo-1D; BAF180; PB1; Protein Polybromo-1; HPB1
- Gene ID
- 55193
- UniProt ID
- Q86U86
- Cellular Localization
- Nucleus
- Post Translation Modifications
- Ubiquitination at Lys754, Lys1398, Lys1626, and Lys1642 (NX_Q86U86 [NX_Q86U86-1])
Modification sites at PhosphoSitePlus (Q86U86)
Glycosylation from GlyGen (Q86U86) 3 sites, 1 O-linked glycan (3 sites)
- Protein Refseq
- XP_011532204.1
- Function
- Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology).
Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF).
Acts as a negative regulator of cell proliferation.
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IgG Antibody Products
IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
| CAT | Product Name | Application | Type |
|---|---|---|---|
| DrMAB-430 | Recombinant Human Anti-Human PBRM1 Antibody, clone D466 | ELISA, IP-MS | IgG |
| VS3-WK1049 | Mouse Anti-PBRM1 Recombinant Antibody (VS3-WK1049) | WB | Mouse IgG |
| VS3-XY3458 | Rabbit Anti-PBRM1 Recombinant Antibody (clone R04-4L8) | WB, IHC-P, ICC, IF, FC | Rabbit IgG |
| VS13-YC873 | Rabbit Anti-PBRM1 Recombinant Antibody (VS13-YC873) | IHC-P | Rabbit IgG |
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