Rabbit Anti-PBRM1 Recombinant Antibody (clone R04-4L8) (CAT#: VS3-XY3458)

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human, Mouse and Rat PBRM1

• Species Reactivity
• Human, Mouse, Rat

• Clone
• R04-4L8

• Applications
• WB, IHC-P, ICC, IF, FC

• Related Disease
• Renal Cell Carcinoma; Nonpapillary; Clear Cell Papillary Renal Cell Carcinoma

• Clonality
• Monoclonal

• Aggregation
• < 5%

• Format
• Liquid

• Buffer
• PBS (pH 7.4), 150 mM NaCl and 50% glycerol

• Preservative
• 0.02% sodium azide

• Storage
• Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• WB: 1/500-1/1000
  IHC: 1/50-1/100
  IF: 1/50-1/200
  FC: 1/50-1/100

• Alternative Names
• PB1; RCC; BAF180; SMARCH1

• Gene ID
• 55193

• UniProt ID
• Q86U86

• Long Name
• Polybromo 1

• Cellular Localization
• Nucleus

• Post Translation Modifications
• Ubiquitination at Lys754, Lys1398, Lys1626, and Lys1642 (NX_Q86U86 [NX_Q86U86-1])
  Modification sites at PhosphoSitePlus (Q86U86)
  Glycosylation from GlyGen (Q86U86) 3 sites, 1 O-linked glycan (3 sites)

• Protein Refseq
• XP_011532204.1

• Function
• Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology).
  Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF).
  Acts as a negative regulator of cell proliferation.

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Recommended Dilution Buffer

• MRO-0253YJ
• Reconstitution Buffer PBS

Secondary Antibody

• 2RD-A1473-YJ
• Goat Anti-Rabbit IgG-F(ab')2 Secondary antibody

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