Mouse Anti-PECAM1 Recombinant Antibody (VS3-FY2769) (CAT#: VS3-FY2769)

The anti-PECAM1 antibody is a mouse IgG recombinant monoclonal antibody. It showcases a superior level of effectiveness in binding to human CD31 protein. The monoclonal antibody is suitable for use in the research of Angiosarcoma and Hemangioma.

Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Formats:
  • Isotype Switching:
  • Fc Engineering:
  • Modalities:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Host Species
  • Mouse
  • Type
  • Mouse IgG
  • Specificity
  • Platelet and endothelial cell adhesion molecule 1 of human
  • Species Reactivity
  • Human
  • Applications
  • WB, IP
  • Conjugate
  • Unconjugated, FITC
  • Related Disease
  • Angiosarcoma and Hemangioma

Product Property

  • Clonality
  • Monoclonal Antibody
  • Format
  • Liquid
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

Applications

  • Application Notes
  • Immunoprecipitation: 1/20
    Western Blot: 1/500-1/1000

Target

  • Alternative Names
  • Platelet And Endothelial Cell Adhesion Molecule 1; CD31 Antigen; EndoCAM; PECAM-1; GPIIA; PECA1
  • Cellular Localization
  • Cell junction, Cell membrane, Membrane
  • Post Translation Modifications
  • Phosphorylated on Ser and Tyr residues after cellular activation by src kinases.
    Upon activation, phosphorylated on Ser-729 which probably initiates the dissociation of the membrane-interaction segment (residues 709-729) from the cell membrane allowing the sequential phosphorylation of Tyr-713 and Tyr-690.
    Constitutively phosphorylated on Ser-734 in resting platelets.
    Phosphorylated on tyrosine residues by FER and FES in response to FCER1 activation (By similarity).
    In endothelial cells Fyn mediates mechanical-force (stretch or pull) induced tyrosine phosphorylation.
    Palmitoylation by ZDHHC21 is necessary for cell surface expression in endothelial cells and enrichment in membrane rafts.
  • Function
  • Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (PubMed:19342684, PubMed:17580308).
    Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (PubMed:19342684).
    Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions (PubMed:27958302).
    Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (PubMed:17580308).
    Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (PubMed:12110892).
    Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (PubMed:12110892).
    Modulates bradykinin receptor BDKRB2 activation (PubMed:18672896).
    Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells (PubMed:18672896).
    Induces susceptibility to atherosclerosis (By similarity).
    Isoform Delta15: Does not protect against apoptosis.

Recommended Products

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

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CAT Product Name Application Type
NEUT-1852CQ Recombinant Mouse Anti-PECAM1 Antibody (HEC7) BL, ELISA, FC, ICC/IF, IHC, IP, WB IgG2a
NEUT-1855CQ Recombinant Mouse Anti-PECAM1 Antibody (WM59) FC, IHC, IF, BL IgG1, κ
NEUT-1856CQ Recombinant Rat Anti-Pecam1 Antibody (390) FC, IP, IHC-Fr, ICC, BL IgG2a, κ

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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