AbPlus™ Anti-PFKFB3 Magnetic Beads (VS-0724-YC872)
CAT#: VS-0724-YC872
The AbPlus Anti-PFKFB3 Magnetic Beads (VS-0724-YC872) is an innovative affinity resin which is bound with anti-PFKFB3 specific antibody. The beads were designed for small-scale affinity purification and immunoprecipitation (IP) of PFKFB3 protein under native and denaturing conditions.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8266/if_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line A549
Immunofluorescent staining of human cell line A549 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/43889/if_selected.jpg
Normal Tissue
Figure 3 IHC staining of human rectum
Immunohistochemical staining of human rectum shows moderate cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20795/48008_A_5_3_selected.jpg
Normal Tissue
Figure 4 Lymph node
Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20795/48008_A_7_8.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20795/48008_A_7_5.jpg
Normal Tissue
Figure 6 Bone marrow
Hematopoietic cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20795/48008_B_6_4.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (A549, RPTEC TERT1, T-47d)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000170525-PFKFB3
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Specifications
- Applications
- Immunoprecipitation, Protein Purification
- Matrix
- Magnetic bead
- Bead Ligand
- Anti-PFKFB3 specific antibody
- Target
- PFKFB3
- Immunogen
- Recombinant human PFKFB3 fragment derived from E. coli.
- Target Species
- Human
- Bead Capacity
- 40 mg/mL
- Bead size
- 25 μm
- Format
- Suspension
- Concentration
- 2 mg/mL
- Buffer
- PBS, pH 7.4
- Preservative
- 0.1% Sodium azide
- Storage
- Stored at 4°C, and is stable for up to 2 years. Do not centrifuge, dry or freeze the magnetic beads.
Applications
- Application Notes
- The beads are in suspension and will settle upon storage. Prior to use, mix the vial gently (do not vortex) to ensure delivery of proper bead volume.
Target
- Introduction
- The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2016]
- Alternative Names
- 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3; PF-2-K/Fru-2,6-P2ase Brain/Placenta-Type Isozyme; Renal Carcinoma Antigen NY-REN-56; PF-2-K/Fru-2,6-P2ase 3; PFK/FBPase 3; IPFK-2; Inducible 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase;
- Gene ID
- 5209
- UniProt ID
- Q16875
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "PFKFB3"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2204z | Mouse Anti-PFKFB3 Recombinant Antibody (clone 23H7) | ELISA, WB, IP | Mouse IgG2a, κ |
| MRO-1210-CN | Recombinant Rabbit Anti-PFKFB3 Monoclonal Antibody (JM43-43) | WB, IF, IHC, FC, IP | Rabbit IgG |
| VS3-WK587 | Rabbit Anti-PFKFB3 Recombinant Antibody (clone JM43-43) | WB, ELISA | Rabbit IgG |
| VS3-FY1124 | Recombinant Rabbit Anti-PFKFB3 Antibody (clone R08-7A4) | WB, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2670 | Hi-Affi™ Recombinant Rabbit Anti-PFKFB3 Monoclonal Antibody (DS2670AB) | WB, IP, ICC, IF, IHC-P | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS13-YC896 | CytoStream™ Rabbit Anti-PFKFB3 Recombinant Antibody (VS13-YC896) | WB, ICC, IF, IHC-P, FC, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY5322 | Anti-PFKFB3 Immunohistochemistry Kit | IHC |
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