Rabbit Anti-PPP1CB Recombinant Antibody (clone R09-6B7) (CAT#: VS3-FY1844)

• Immunogen
• Synthetic peptide of human PPP1CB

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human, Mouse and Rat PPP1CB

• Species Reactivity
• Human, Mouse, Rat

• Clone
• R09-6B7

• Applications
• Western Blot, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Immunofluorescence, Immunoprecipitation

• MW
• The calculated weight of the target protein is approximately 37 kDa, while the observed molecular weight stands at 37 kDa.

• Related Disease
• Noonan Syndrome-Like Disorder With Loose Anagen Hair 2 and Noonan Syndrome-Like Disorder With Loose Anagen Hair

• Purification
• Affinity Purified

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/1000
  Immunohistochemistry: 1/50-1/100
  Immunofluorescence: 1/50-1/200
  Immunoprecipitation: 1/20

• Alternative Names
• MP; PP1B; PP1c; NSLH2; PP-1B; PPP1CD; PP1beta; PPP1beta; HEL-S-80p

• Gene ID
• 5500

• UniProt ID
• P62140

• Sequence Similarities
• Belongs to the PPP phosphatase family. PP-1 subfamily.

• Cellular Localization
• Cytoplasm, Nucleus

• Post Translation Modifications
• Ubiquitination at Lys25 and Lys303 (NX_P62140 [NX_P62140-1])
  Modification sites at PhosphoSitePlus (P62140)
  Glycosylation from GlyGen (P62140) 1 site, 1 O-linked glycan (1 site)

• Protein Refseq
• NP_002700.1; NP_996759.1

• Function
• Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective.

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Secondary Antibody

• 2ND-054CQ
• Goat Anti-Rabbit IgG Antibody, R-PE

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-055CQ
• Chicken Anti-Rabbit IgG (H&L) Antibody

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