Rabbit Anti-PPP2CA/PPP2CB Recombinant Antibody (VS3-CJ1090) (CAT#: VS3-CJ1090)

• Immunogen
• Recombinant protein

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human, Mouse, Rat, Zebrafish PPP2CA/B

• Species Reactivity
• Human, Mouse, Rat, Zebrafish

• Applications
• WB, ICC, IHC, IP

• Conjugate
• Unconjugated

• Purification
• Protein A affinity purified

• Purity
• >95% as determined by SDS-PAGE

• Format
• Liquid

• Buffer
• 40% Glycerol, 1% BSA, TBS, pH7.4.

• Preservative
• 0.05% Sodium Azide

• Storage
• Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• This antibody has been tested for use in Western Blot, Immunocytochemistry, Immunohistochemistry, Immunoprecipitation.

• Alternative Names
• RP-C; PP2Ac; PP2CA; NEDLBA; PP2Calpha; PP2CB; PP2Abeta

• Gene ID
• 5516

• UniProt ID
• P62714

• Sequence Similarities
• Belongs to the PPP phosphatase family. PP-1 subfamily.

• Cellular Localization
• Centromere, Chromosome, Cytoplasm, Cytoskeleton, Nucleus

• Post Translation Modifications
• Reversibly methyl esterified on Leu-309 by leucine carboxyl methyltransferase 1 (LCMT1) and protein phosphatase methylesterase 1 (PPME1). Carboxyl methylation influences the affinity of the catalytic subunit for the different regulatory subunits, thereby modulating the PP2A holoenzyme's substrate specificity, enzyme activity and cellular localization.
  Phosphorylation of either threonine (by autophosphorylation-activated protein kinase) or tyrosine results in inactivation of the phosphatase. Auto-dephosphorylation has been suggested as a mechanism for reactivation.
  May be monoubiquitinated by NOSIP.

• Protein Refseq
• NP_001009552.1

• Function
• Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events (Probable). PP2A can modulate the activity of phosphorylase B kinase, casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase.

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Secondary Antibody

• 2ND-057CQ
• Donkey Anti-Rabbit IgG (H&L) Antibody

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody