Rabbit Anti-PSENEN Recombinant Antibody (clone R08-5F0) (CAT#: VS3-FY2060)
The R08-5F0 is a rabbit recombinant monoclonal antibody that exhibits specific binding to human PSENEN. It cross-reacts with mouse, rat. It is suitable for use in a variety of assays, including WB, IHC-F, IHC-P, ICC/IF. The R08-5F0 is recommended for dilution of target protein by western blot (dilution 1/500-1/1000), immunohistochemistry (dilution 1/50-1/100), immunofluorescence (dilution 1/50-1/200).
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ICC
Figure 1 Anti-PEN2 Antibody (VS3-FY2060) in ICC.
Immunocytochemistry staining of PEN2 (green) in Hela using the anti-PEN2 antibody. Nuclear DNA was labeled with DAPI (shown in blue).
WB
Figure 2 Anti-PEN2 Antibody (VS3-FY2060) in WB.
The PEN2 expression in Raw264.7, mouse brain lysates were detected using the anti-PEN2 by western blot assay.
Specifications
- Immunogen
- Synthetic peptide of human PEN2
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat PSENEN
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R08-5F0
- Applications
- Western Blot, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Immunofluorescence
- MW
- The calculated weight of the target protein is approximately 12 kDa, while the observed molecular weight stands at 12 kDa.
- Related Disease
- Acne Inversa, Familial, 2, With Or Without Dowling-Degos Disease and Dowling-Degos Disease
Product Property
- Purification
- Affinity Purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% glycerol, 0.05% BSA
- Preservative
- 0.01% Sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Immunohistochemistry: 1/50-1/100
Immunofluorescence: 1/50-1/200
Target
- Alternative Names
- PSENEN; MSTP064; PEN-2; PEN2; MDS033; presenilin enhancer gamma-secretase subunit; ACNINV2; presenilin enhancer; gamma-secretase subunit
- Gene ID
- 55851
- UniProt ID
- Q9NZ42
- Sequence Similarities
- Belongs to the PEN-2 family.
- Cellular Localization
- Cell membrane, Endoplasmic reticulum, Golgi apparatus, Membrane
- Post Translation Modifications
- Modification sites at PhosphoSitePlus (Q9NZ42)
Modification sites at neXtProt (NX_Q9NZ42)
- Protein Refseq
- NP_001268461.1; NP_758844.1
- Function
- The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable). PSENEN modulates both endoproteolysis of presenilin and gamma-secretase activity.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "PSENEN"
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IgG Antibody Products
Rabbit Monoclonal Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0971MZ | Recombinant Mouse Anti-Human PSENEN Antibody | WB | Mouse antibody |
| MRO-1203-CN | Recombinant Rabbit Anti-PSENEN Monoclonal Antibody (JE41-28) | WB, IF, IHC, FC | Rabbit IgG |
| VS3-WK354 | Rabbit Anti-PSENEN Recombinant Antibody (clone JE41-28) | WB, ELISA | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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