Mouse Anti-RAB8A Recombinant Antibody (VS3-CJ1072)
CAT#: VS3-CJ1072
This product is a mouse antibody that recognizes human, and mouse RAB8A.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/41945/if_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000167461-RAB8A
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Specifications
- Immunogen
- Recombinant protein of RAB8A
- Host Species
- Mouse
- Type
- Mouse IgG1, κ
- Specificity
- Human, Mouse RAB8A
- Species Reactivity
- Human, Mouse
- Applications
- WB
- Conjugate
- Unconjugated
Product Property
- Purification
- Protein G affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- PBS
- Preservative
- 0.09% Sodium Azide
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been tested for use in Western Blot (1:1000).
Target
- Alternative Names
- MEL; RAB8
- Gene ID
- 4218
- UniProt ID
- P61006
- Sequence Similarities
- Belongs to the small GTPase superfamily. Rab family.
- Cellular Localization
- Cell membrane, Cell projection, Cilium, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Endosome, Golgi apparatus, Membrane
- Post Translation Modifications
- Phosphorylation of Thr-72 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitors GDI1 and GDI2.
- Protein Refseq
- NP_005361.2
- Function
- The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (PubMed:20890297).
Regulates the compacted morphology of the Golgi (PubMed:26209634).
Together with MYO5B and RAB11A participates in epithelial cell polarization (PubMed:21282656).
Also involved in membrane trafficking to the cilium and ciliogenesis (PubMed:21844891, PubMed:30398148).
Together with MICALL2, may also regulate adherens junction assembly (By similarity).
May play a role in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore play a role in glucose homeostasis (By similarity).
Involved in autophagy (PubMed:27103069).
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
See other products for "RAB8A"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-012CQ | Mouse Anti-Human Rab8 Antibody | ELISA, WB, FC | Mouse IgG |
| VS3-FY1600 | Rabbit Anti-RAB8A Recombinant Antibody (clone R06-8A7) | WB, IHC-Fr, IHC-P, IF | Rabbit IgG |
| VS13-YC972 | Rabbit Anti-RAB8A Recombinant Antibody (VS13-YC972) | WB | Rabbit IgG |
| VS7-0425-WR747 | Mouse Anti-RAB8A Recombinant Antibody (clone 7G8B11) | FC | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY5936 | Anti-RAB8A Immunohistochemistry Kit | IHC |
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