Rabbit Anti-RAB8A Recombinant Antibody (clone R06-8A7) (CAT#: VS3-FY1600)

• Immunogen
• Synthetic peptide of human RAB8A

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human, Mouse and Rat RAB8A

• Species Reactivity
• Human, Mouse, Rat

• Clone
• R06-8A7

• Applications
• Western Blot, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Immunofluorescence

• MW
• The calculated weight of the target protein is approximately 24 kDa, while the observed molecular weight stands at 24 kDa.

• Related Disease
• Microvillus Inclusion Disease and Open-Angle Glaucoma

• Purification
• Affinity Purified

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/1000
  Immunohistochemistry: 1/50-1/100
  Immunofluorescence: 1/50-1/200

• Alternative Names
• RAB8A, Member RAS Oncogene Family; Mel Transforming Oncogene (Derived From Cell Line NK14); Oncogene C-Mel; RAB8; MEL; Mel Transforming Oncogene (Derived From Cell Line NK14)- RAB8 Homolog; Mel Transforming Oncogene (RAB8 Homolog); Ras-Associated Protein RAB8; Ras-Related Protein Rab-8A

• Gene ID
• 4218

• UniProt ID
• P61006

• Sequence Similarities
• Belongs to the small GTPase superfamily. Rab family.

• Cellular Localization
• Cell membrane, Cell projection, Cilium, Cytoplasm, Cytoplasmic vesicle

• Post Translation Modifications
• Phosphorylation of Thr-72 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitors GDI1 and GDI2.

• Protein Refseq
• NP_005361.2

• Function
• The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis.
  Regulates the compacted morphology of the Golgi.
  Together with MYO5B and RAB11A participates in epithelial cell polarization.
  Also involved in membrane trafficking to the cilium and ciliogenesis.
  Together with MICALL2, may also regulate adherens junction assembly (By similarity).
  May play a role in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore play a role in glucose homeostasis (By similarity).

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Secondary Antibody

• 2ND-054CQ
• Goat Anti-Rabbit IgG Antibody, R-PE

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-055CQ
• Chicken Anti-Rabbit IgG (H&L) Antibody

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