Rabbit Anti-RELB Recombinant Antibody (clone R02-8F7)
CAT#: VS3-XY3486
This product is a recombinant rabbit antibody that recognizes RELB (RELB proto-oncogene, NF-kB subunit). The antibody specifically recognizes human RELB. It also has cross-reactivity against mouse and rat RELB. This antibody has been reported for use in Western Blot, Immunohistochemistry-Paraffin, Immunoprecipitation, Flow cytometry, Immunocytochemistry or Immunofluorescence.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/40506/if_selected.jpg
Normal Tissue
Figure 2 Lymph node
Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: nuclear Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/40506/92847_A_9_8.jpg
Normal Tissue
Figure 3 Hippocampus
Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/40506/92847_B_9_6.jpg
Normal Tissue
Figure 4 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Nuclear Glandular cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Nuclear Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/40506/92847_A_9_3.jpg
Normal Tissue
Figure 5 Liver
Hepatocytes Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/40506/92847_A_8_4.jpg
Normal Tissue
Figure 6 Kidney
Cells in glomeruli Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/40506/92847_A_8_5.jpg
Normal Tissue
Figure 7 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: nuclear Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/40506/92847_A_5_6.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (Daudi, HDLM-2, U-698)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000104856-RELB
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Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat RELB
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R02-8F7
- Applications
- WB, IHC-P, ICC, IF, IP, FC
- Related Disease
- Immunodeficiency 53; Reticuloendotheliosis
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IHC: 1/50-1/100
IF: 1/50-1/200
IP: 1/20
FC: 1/50-1/100
Target
- Alternative Names
- IREL; I-REL; IMD53; REL-B
- Gene ID
- 5971
- UniProt ID
- Q01201
- Long Name
- RELB proto-oncogene, NF-kB subunit
- Cellular Localization
- Nucleus, Cytoplasm
- Post Translation Modifications
- Phosphorylation at 'Thr-103' and 'Ser-573' is followed by proteasomal degradation. (Q01201-RELB_HUMAN)
Modification sites at PhosphoSitePlus (Q01201)
Modification sites at neXtProt (NX_Q01201)
Glycosylation from GlyGen (Q01201) 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- XP_047295145.1
- Function
- NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis.
NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52.
The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "RELB"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3044 | Hi-Affi™ Recombinant Rabbit Anti-RELB Monoclonal Antibody (DS3044AB) | ICC, IF, IHC-P, IP, WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-XY1367 | Mouse Anti-RELB Recombinant Antibody (clone 2E4B1) | ICC, FC | Mouse IgG2a |
| VS3-WK841 | Mouse Anti-RELB Recombinant Antibody (VS3-WK841) | WB | Mouse IgG |
| VS3-WK842 | Rabbit Anti-RELB Recombinant Antibody (VS3-WK842) | WB, ICC, IF, IHC, IP | Rabbit IgG |
| VS3-FY1266 | Recombinant Rabbit Anti-RELB Antibody (clone R07-9J3) | WB, IP | Rabbit IgG |
| VS13-YC1000 | Rabbit Anti-RELB Recombinant Antibody (VS13-YC1000) | WB, ICC, IF, IHC-P, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY445 | Rabbit Anti-NHP RELB Recombinant Antibody (VS-1024-XY445) | WB, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1906 | Anti-RELB Immunohistochemistry Kit | IHC | |
| VS-0525-XY6075 | Anti-Mouse RELB Immunohistochemistry Kit | IHC | |
| VS-0525-XY6074 | Anti-Human RELB Immunohistochemistry Kit | IHC |
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