Rabbit Anti-SEPT7 Recombinant Antibody (clone R09-6A1) (CAT#: VS3-FY1880)

• Immunogen
• Recombinant human SEPT7 protein

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human, Mouse and Rat SEPT7

• Species Reactivity
• Human, Mouse, Rat

• Clone
• R09-6A1

• Applications
• Western Blot, Immunofluorescence

• MW
• The calculated weight of the target protein is approximately 51 kDa, while the observed molecular weight stands at 51 kDa.

• Related Disease
• Amyotrophic Neuralgia and Brachial Plexus Neuropathy

• Purification
• Affinity Purified

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/1000
  Immunofluorescence: 1/50-1/200

• Alternative Names
• Septin 7; CDC10 Protein Homolog; CDC10; CDC10 (Cell Division Cycle 10, S. Cerevisiae, Homolog); CDC10 Cell Division Cycle 10 Homolog (S. Cerevisiae); Septin 7 Variant 4

• Gene ID
• 989

• UniProt ID
• Q16181

• Sequence Similarities
• Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

• Cellular Localization
• Cell projection, Centromere, Chromosome, Cilium, Cytoplasm

• Post Translation Modifications
• Ubiquitination at Lys89, Lys298, and Lys313 (NX_Q16181 [NX_Q16181-1])
  Modification sites at PhosphoSitePlus (Q16181)
  Glycosylation from GlyGen (Q16181) 6 sites, 1 O-linked glycan (6 sites)

• Protein Refseq
• XP_006715869.1; XP_011513958.1; XP_011513963.1; XP_047277051.1; XP_047277052.1

• Function
• Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis and collective cell movements. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation.

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Secondary Antibody

• 2ND-054CQ
• Goat Anti-Rabbit IgG Antibody, R-PE

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-055CQ
• Chicken Anti-Rabbit IgG (H&L) Antibody

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