Anti-SOX2 (clone W24V245) Recombinant Antibody Coupled Liposome (VS-1024-FY243)
CAT#: VS-1024-FY243
Anti-Sox2 antibody conjugated liposomes hold significant potential in research, particularly for targeting subcutaneous F9 teratocarcinoma tumors. By specifically binding to Sox2, a stem cell marker associated with tumor progression and maintenance, these liposomes can enhance the precision of therapeutic interventions. This targeted approach may improve the efficacy of drug delivery while minimizing off-target effects, thereby reducing systemic toxicity. Furthermore, studying the interactions and efficacy of these conjugated liposomes could provide insights into stem cell characteristics in tumors and contribute to the development of more effective cancer therapies.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/45725/if_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line HEK 293
Immunofluorescent staining of human cell line HEK 293 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/62851/1273_B4_7_selected.jpg
Normal Tissue
Figure 3 High expression in cerebral cortex
Glial cells Staining: Medium Intensity: Strong Quantity: <25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/79745/167827_B_9_5.jpg
Normal Tissue
Figure 4 Esophagus
Squamous epithelial cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/79745/167827_B_6_1.jpg
Normal Tissue
Figure 5 Colon
Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity: 75%-25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/79745/167827_A_7_3.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (AF22, HAP1, NTERA-2, U-251 MG)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000181449-SOX2
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More Infomation
Specifications
- Potential Clinical Applications
- Subcutanous F9 teratocarcinoma tumours
Product Composition
- Clone
- W24V245
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant mouse monoclonal antibody that was engineered to selectively bind to the Sox2 protein, which is crucial for maintaining pluripotency in stem cells. Sox2 functions as a transcription factor that regulates the expression of genes involved in stem cell maintenance and development. The specificity of this antibody allows researchers to delve deeper into the mechanisms of stem cell biology and the potential therapeutic applications associated with Sox2.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- SOX2
- Full Name
- SRY-Box 2
- Cellular Localization
- Cytoplasm, Nucleus
- Post Translation Modifications
- Sumoylation inhibits binding on DNA and negatively regulates the FGF4 transactivation.
Methylation at Lys-42 and Lys-117 is necessary for the regulation of SOX2 proteasomal degradation.
- Protein Refseq
- NP_003097.1
- Function
- Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity).
Binds to the proximal enhancer region of NANOG (By similarity).
Critical for early embryogenesis and for embryonic stem cell pluripotency (PubMed:18035408).
Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity).
Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).
May function as a switch in neuronal development (By similarity).
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Datasheet
MSDS
COA
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See other products for "SOX2"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2438z | Mouse Anti-SOX2 Recombinant Antibody (clone 44A5) | WB, ELISA, IHC | Mouse IgG2b, κ |
| MRO-2197-CN | Rabbit Anti-SOX2 Polyclonal Antibody (MRO-2197-CN) | WB, IHC, FC | Rabbit IgG |
| VS3-QX1042 | Mouse Anti-SOX2 Recombinant Antibody (clone 2A10-F11-F12) | WB, FC, ICC | Mouse IgG1 |
| VS3-QX1043 | Mouse Anti-SOX2 Recombinant Antibody (clone 57CT23.3.4) | WB, ICC, IHC, FC | Mouse IgG1 |
| VS3-QX1044 | Mouse Anti-SOX2 Recombinant Antibody (clone 10F10C9) | WB, IHC, ICC, FC, ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3377 | Hi-Affi™ Recombinant Rabbit Anti-SOX2 Monoclonal Antibody (DS3377AB) | ICC, IHC-P, WB, sELISA | IgG |
| MOR-0107-FY | Rabbit Anti-SOX2 Recombinant Antibody (clone AFY0078) | ICC, IHC-P, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN0275 | APC-A*02:01/Human SOX2 (SMYLPGAEV) MHC Tetramer | FCM | |
| MHC-CN0276 | PE-A*02:01/Human SOX2 (SMYLPGAEV) MHC Tetramer | FCM | |
| MHC-CN0303 | APC-A*02:01/Human SOX2 (TLMKKDKYTL) MHC Tetramer | FCM | |
| MHC-CN0304 | PE-A*02:01/Human SOX2 (TLMKKDKYTL) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC574 | AbPlus™ Anti-SOX2 Magnetic Beads (VS-0724-YC574) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC90 | Mouse Anti-SOX2 Recombinant Antibody (VS-0924-YC90) - Cancer Stem Cell Marker | IHC, WB, IF | Mouse IgG1 |
| VS-0924-YC91 | Rabbit Anti-SOX2 Antibody (VS-0924-YC91) - Cancer Stem Cell Marker | WB, IF | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY201 | CytoStream™ Mouse Anti-SOX2 Recombinant Antibody (clone 245610) | FC | Mouse IgG2a |
| VS-0225-XY202 | CytoStream™ Mouse Anti-SOX2 Recombinant Antibody (VS-0225-XY202) | FC | Mouse IgG1, kappa |
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