Anti-SOX2 (clone W24V245) Recombinant Antibody Coupled Liposome (VS-1024-FY243) (CAT#: VS-1024-FY243)

• Potential Clinical Applications
• Subcutanous F9 teratocarcinoma tumours

• Clone
• W24V245

• Antibody Type
• IgG

• Antibody Host
• Mouse

• Antibody Reactivity
• Human

• Antibody Description
• This is a recombinant mouse monoclonal antibody that was engineered to selectively bind to the Sox2 protein, which is crucial for maintaining pluripotency in stem cells. Sox2 functions as a transcription factor that regulates the expression of genes involved in stem cell maintenance and development. The specificity of this antibody allows researchers to delve deeper into the mechanisms of stem cell biology and the potential therapeutic applications associated with Sox2.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• SOX2

• Full Name
• SRY-Box 2

• Cellular Localization
• Cytoplasm, Nucleus

• Post Translation Modifications
• Sumoylation inhibits binding on DNA and negatively regulates the FGF4 transactivation.
  Methylation at Lys-42 and Lys-117 is necessary for the regulation of SOX2 proteasomal degradation.

• Protein Refseq
• NP_003097.1

• Function
• Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity).
  Binds to the proximal enhancer region of NANOG (By similarity).
  Critical for early embryogenesis and for embryonic stem cell pluripotency (PubMed:18035408).
  Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity).
  Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).
  May function as a switch in neuronal development (By similarity).

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