Anti-STEAP1 (clone 120.545) Recombinant Antibody Coupled Liposome (VS-1024-FY306)
CAT#: VS-1024-FY306
Anti-STEAP1 antibody conjugated liposomes hold significant potential in prostate cancer research by enabling targeted delivery of therapeutic agents directly to STEAP1-expressing tumor cells, thereby enhancing treatment efficacy while minimizing systemic side effects. Furthermore, their use in diagnostic imaging could improve the identification and monitoring of prostate cancer, paving the way for more personalized treatment strategies.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IHC staining of human lung
Immunohistochemical staining of human lung shows strong cytoplasmic and membranous positivity in pneumocytes.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/30985/ihc_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Neuronal cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Neuropil
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/30985/123719_B_7_5.jpg
Normal Tissue
Figure 3 Prostate
Glandular cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/30985/123719_A_3_5.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced (ASC diff, CAPAN-2, U-138 MG)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000164647-STEAP1/subcellular
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More Infomation
Specifications
- Potential Clinical Applications
- Prostate cancer
Product Composition
- Clone
- 120.545
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This antibody is a recombinant mouse monoclonal that was specifically engineered to target and interact with STEAP1. Its design involves crafting a highly selective affinity for STEAP1, a protein implicated in various cellular processes. By binding to this target, the antibody aims to facilitate research and therapeutic applications related to STEAP1's role in diseases.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- STEAP1
- Introduction
- This gene is predominantly expressed in prostate tissue, and is found to be upregulated in multiple cancer cell lines. The gene product is predicted to be a six-transmembrane protein, and was shown to be a cell surface antigen significantly expressed at cell-cell junctions.
- Alternative Names
- STEAP; PRSS24; STEAP1; STEAP family member 1
- Full Name
- Metalloreductase STEAP1
- Gene ID
- 26872
- UniProt ID
- Q9UHE8
- Sequence Similarities
- Belongs to the STEAP family.
- Cellular Localization
- Endosome membrane
- Post Translation Modifications
- Modification sites at PhosphoSitePlus ( Q9UHE8 )
Modification sites at neXtProt
- Protein Refseq
- NP_036581.1
- Function
- Does not function as a metalloreductase due to the absence of binding sites for the electron-donating substrate NADPH.
Promotes Fe(3+) reduction when fused to the NADPH-binding domain of STEAP4.
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Downloadable Resources
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Datasheet
MSDS
COA
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See other products for "STEAP1"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1961CT | Recombinant Mouse anti-Human STEAP1 Monoclonal antibody (EML1413) | WB | |
| HPAB-N0259-YC | Human Anti-STEAP1 Recombinant Antibody (HPAB-N0259-YC) | FuncS | Humanized IgG |
| HPAB-0487-YJ | Mouse Anti-STEAP1 Recombinant Antibody (HPAB-0487-YJ) | FC, ELISA | Mouse IgG1 |
| HPAB-1208WJ | Mouse Anti-STEAP1 Recombinant Antibody (HPAB-1208WJ) | FC, Inhib | Mouse IgG |
| PABS-0208 | Mouse Anti-STEAP1 Recombinant Antibody (PABS-0208) | ELISA, Inhib | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN0339 | APC-H-2Db/Human STEAP (VSKINRTEM) MHC Tetramer | FCM | |
| MHC-CN0340 | PE-H-2Db/Human STEAP (VSKINRTEM) MHC Tetramer | FCM | |
| MHC-CN1233 | PE-A*02:01/Human STEAP1 (MLAVFLPIV) MHC Tetramer | FCM, IHC | |
| MHC-CN1234 | APC-A*02:01/Human STEAP1 (MLAVFLPIV) MHC Tetramer | FCM, IHC | |
| MHC-CN1235 | FITC-A*02:01/Human STEAP1 (MLAVFLPIV) MHC Tetramer | FCM, IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0259-YC-S(P) | Human Anti-STEAP1 Recombinant Antibody; scFv Fragment (HPAB-N0259-YC-S(P)) | FuncS | Humanized scFv |
| HPAB-0487-YJ-S(P) | Mouse Anti-STEAP1 Recombinant Antibody; scFv Fragment (HPAB-0487-YJ-S(P)) | FC, ELISA | Mouse scFv |
| HPAB-0488-YJ-S(P) | Mouse Anti-STEAP1 Recombinant Antibody; scFv Fragment (HPAB-0488-YJ-S(P)) | FC, ELISA | Mouse scFv |
| HPAB-0489-YJ-S(P) | Human Anti-STEAP1 Recombinant Antibody; scFv Fragment (HPAB-0489-YJ-S(P)) | FC, ELISA | Humanized scFv |
| HPAB-1208WJ-S(P) | Mouse Anti-STEAP1 Recombinant Antibody; scFv Fragment (HPAB-1208WJ-S(P)) | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0259-YC-F(E) | Human Anti-STEAP1 Recombinant Antibody; Fab Fragment (HPAB-N0259-YC-F(E)) | FuncS | Humanized Fab |
| HPAB-0487-YJ-F(E) | Mouse Anti-STEAP1 Recombinant Antibody; Fab Fragment (HPAB-0487-YJ-F(E)) | FC, ELISA | Mouse Fab |
| HPAB-0488-YJ-F(E) | Human Anti-STEAP1 Recombinant Antibody; Fab Fragment (HPAB-0488-YJ-F(E)) | FC, ELISA | Fab |
| HPAB-0489-YJ-F(E) | Human Anti-STEAP1 Recombinant Antibody; Fab Fragment (HPAB-0489-YJ-F(E)) | FC, ELISA | Humanized Fab |
| HPAB-1208WJ-F(E) | Mouse Anti-STEAP1 Recombinant Antibody; Fab Fragment (HPAB-1208WJ-F(E)) | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY186 | Mouse Anti-STEAP1 scFv-Fc Chimera (VS-0425-FY186) | ELISA, WB, IHC, FC | Mouse IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC524 | Recombinant Anti-STEAP1 Vesicular Antibody, EV Displayed (VS-0425-YC524) | ELISA, FC, Inhib, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY6965 | Anti-STEAP1 Immunohistochemistry Kit | IHC |
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