Anti-TBX21 (clone W24V22) Recombinant Antibody Coupled Liposome (VS-1024-FY23)
CAT#: VS-1024-FY23
Anti-T-bet antibody conjugated liposomes may exert their effects by inhibiting T cell activation and affecting the growth of tumor cells that express PD-L1. This mechanism suggests that they may hold potential in the treatment of T-bet related cancers, but further research is needed to understand how they specifically induce cytotoxicity in T cell lines.
Gene Expression
Normal Tissue
Figure 1 Spleen
High expression
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/9524/24853_B_7_4_val_selected.jpg
Normal Tissue
Figure 2 Liver
Hepatocytes Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/30043/70685_A_8_4.jpg
Normal Tissue
Figure 3 Bone marrow
Hematopoietic cells Staining: Medium Intensity: Strong Quantity: <25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/30043/70685_B_5_4.jpg
Normal Tissue
Figure 4 Lymph node
Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/30043/70685_A_9_8.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enriched (HDLM-2)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000073861-TBX21
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More Infomation
Specifications
- Potential Clinical Applications
- Potentially kill T cell lines (e.g. CCRFCEM)
Product Composition
- Clone
- W24V22
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This product is a recombinant antibody derived from mouse sources that specifically targets the T-bet protein. T-bet, or T-box transcription factor TBX21, plays a crucial role in the immune system, particularly in the differentiation of T helper 1 (Th1) cells and the modulation of immune responses. The antibody has been engineered to enhance specificity and affinity for T-bet, making it an invaluable tool for research applications aimed at understanding immune function and the underlying mechanisms of various diseases.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- TBX21
- Introduction
- This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells.
- Alternative Names
- T-Box 21; T-Cell-Specific T-Box Transcription Factor T-Bet; Transcription Factor TBLYM; T-Box Protein 21; TBLYM; TBET
- Full Name
- T-Box 21
- Gene ID
- 30009
- UniProt ID
- Q9UL17
- Cellular Localization
- Nucleus
- Post Translation Modifications
- Phosphorylations at Ser-53, Tyr-77, Ser-225 and Ser-513 are regulated by mTORC1.
Phosphorylation at Tyr-530 is essential for its interaction GATA3.
Phosphorylation at Tyr-220, Tyr-266 and Tyr-305 enhances its transcriptional activator activity.
Phosphorylation at Thr-303 is required for its interaction with NFATC2.
- Protein Refseq
- NP_037483.1
- Function
- Lineage-defining transcription factor which initiates Th1 lineage development from naive Th precursor cells both by activating Th1 genetic programs and by repressing the opposing Th2 and Th17 genetic programs (PubMed:10761931).
Activates transcription of a set of genes important for Th1 cell function, including those encoding IFN-gamma and the chemokine receptor CXCR3.
Induces permissive chromatin accessibilty and CpG methylation in IFNG (PubMed:33296702).
Activates IFNG and CXCR3 genes in part by recruiting chromatin remodeling complexes including KDM6B, a SMARCA4-containing SWI/SNF-complex, and an H3K4me2-methyltransferase complex to their promoters and all of these complexes serve to establish a more permissive chromatin state conducive with transcriptional activation.
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Related Diseases
Inflammatory Bowel Diseases
Downloadable Resources
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
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| IAB-B024(A) | Recombinant Anti-human TBX21 Intrabody [(D-Arg)9] | CO-IP, FuncS | scFv-(D-Arg)9 |
| IAB-B024(G) | Recombinant Anti-human TBX21 Intrabody [+36 GFP] | ELISA, IF, Neut, FuncS | scFv-(+36GFP) |
| IAB-B024(T) | Recombinant Anti-human TBX21 Intrabody [Tat] | ELISA, Neut, FuncS | scFv-Tat |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3514 | Rabbit Anti-TBX21 Recombinant Antibody (clone DS3514AB) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7116 | Anti-TBX21 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7117 | Anti-Mouse TBX21 Immunohistochemistry Kit | IHC |
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