Rabbit Anti-TMEM67 Recombinant Antibody (clone R07-2A4) (CAT#: VS3-FY2032)
The anti-Meckelin antibody applied to in western blot analysis of meckelin in Hela, A549, HL-60, U251, U87-MG lysates. The recombinant monoclonal antibody effectively recognizes human TMEM67. It is suitable for use in a variety of assays, including WB, ICC/IF.
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WB
Figure 1 Anti-TMEM67 Antibody (VS3-FY2032) in WB.
The Meckelin expression in Hela, A549, HL-60, U251, U87-MG lysates were detected using the anti-Meckelin by western blot assay.
Specifications
- Immunogen
- Human Mecklin synthetic peptide
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human TMEM67
- Species Reactivity
- Human
- Clone
- R07-2A4
- Applications
- Western Blot, Immunofluorescence
- MW
- The calculated weight of the target protein is approximately 112 kDa, while the observed molecular weight stands at 112 kDa.
- Related Disease
- Rhyns Syndrome and Coach Syndrome 1
Product Property
- Purification
- Affinity Purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% glycerol, 0.05% BSA
- Preservative
- 0.01% Sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Immunofluorescence: 1/50-1/200
Target
- Alternative Names
- Transmembrane Protein 67; Meckel Syndrome Type 3 Protein; Meckelin; MKS3; Meckel Syndrome, Type 3; NPHP11; TNEM67; JBTS6
- Gene ID
- 91147
- UniProt ID
- Q5HYA8
- Cellular Localization
- Cell membrane, Cell projection, Cilium, Cytoplasm, cytoskeleton, cilium basal body, Endoplasmic reticulum membrane
- Post Translation Modifications
- Glycosylation at Asn141, Asn179, Asn242, and Asn318 (NX_Q5HYA8 [NX_Q5HYA8-1])
Modification sites at PhosphoSitePlus (Q5HYA8)
Glycosylation from GlyGen (Q5HYA8) 4 sites
- Protein Refseq
- XP_006716749.1; XP_011515665.1; XP_047278365.1; XP_047278366.1; XP_054217460.1
- Function
- Required for ciliary structure and function. Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity).
Involved in centrosome migration to the apical cell surface during early ciliogenesis. Involved in the regulation of cilia length and appropriate number through the control of centrosome duplication. Is a key regulator of stereociliary bundle orientation (By similarity).
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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For Research Use Only. Not For Clinical Use.
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