Anti-TNC (clone F16-131I) Recombinant Antibody Coupled Liposome (VS-1024-FY135) (CAT#: VS-1024-FY135)

• Potential Clinical Applications
• Glioma

• Clone
• F16-131I

• Antibody Type
• IgG

• Antibody Host
• Human

• Antibody Reactivity
• Human

• Antibody Description
• This refers to a recombinant human monoclonal antibody that is engineered to specifically recognize and bind to human tenascin-C (Tnc), a glycoprotein found in the extracellular matrix. Tenascin-C plays a significant role in tissue development, repair, and cellular interactions, making it an important target in various biomedical research areas.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• TNC

• Introduction
• This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration.

• Alternative Names
• GP; JI; TN; HXB; GMEM; TN-C; DFNA56; 150-225

• Full Name
• Tenascin C

• Gene ID
• 3371

• UniProt ID
• P24821

• Sequence Similarities
• Belongs to the tenascin family.

• Cellular Localization
• Secreted, extracellular space, extracellular matrix

• Post Translation Modifications
• Glycosylation at Asn38, Asn166, Asn184, Asn327, Asn788, Asn1018, Asn1034, Asn1079, Asn1445, Asn1455, Asn1093, Asn1119, Asn1485, Asn1534, Asn1809, Asn1184, Asn1210, Asn1261, Asn1275, Asn1301, Asn1366, Asn1392, and Asn2162 ( NX_P24821 [NX_P24821-1] )
  Modification sites at PhosphoSitePlus ( P24821 )
  Glycosylation from GlyConnect TENA_HUMAN (1792)
  Glycosylation from GlyGen (P24821) 32 sites, 203 N-linked glycans (15 sites), 2 O-linked glycans (8 sites)

• Protein Refseq
• XP_005252029.1; XP_005252030.1; XP_005252031.1; XP_005252032.1; XP_006717159.1

• Function
• Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration.
  Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes.
  Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6.
  In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells.

• VS-0425-FY187
• Human Anti-TNC (clone F16-131I) scFv-Fc Chimera

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