Anti-TNC (clone F16-131I) Recombinant Antibody Coupled Liposome (VS-1024-FY135)
CAT#: VS-1024-FY135
The application of anti-TNC antibody-conjugated liposomes in gliomas primarily involves targeted delivery of drugs or therapeutic agents. These liposomes can specifically target glioma cells through the selective binding of anti-TNC antibodies, thereby enhancing the effectiveness of treatment and reducing the impact on normal cells.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Neuropil
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4592/12212_B_7_5.jpg
Normal Tissue
Figure 2 Kidney
Cells in glomeruli
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4823/13810_A_8_5.jpg
Normal Tissue
Figure 3 Testis
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4592/12212_A_5_6.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced.
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000041982-TNC
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More Infomation
Specifications
- Potential Clinical Applications
- Glioma
Product Composition
- Clone
- F16-131I
- Antibody Type
- IgG
- Antibody Host
- Human
- Antibody Reactivity
- Human
- Antibody Description
- This refers to a recombinant human monoclonal antibody that is engineered to specifically recognize and bind to human tenascin-C (Tnc), a glycoprotein found in the extracellular matrix. Tenascin-C plays a significant role in tissue development, repair, and cellular interactions, making it an important target in various biomedical research areas.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- TNC
- Introduction
- This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration.
- Alternative Names
- GP; JI; TN; HXB; GMEM; TN-C; DFNA56; 150-225
- Full Name
- Tenascin C
- Gene ID
- 3371
- UniProt ID
- P24821
- Sequence Similarities
- Belongs to the tenascin family.
- Cellular Localization
- Secreted, extracellular space, extracellular matrix
- Post Translation Modifications
- Glycosylation at Asn38, Asn166, Asn184, Asn327, Asn788, Asn1018, Asn1034, Asn1079, Asn1445, Asn1455, Asn1093, Asn1119, Asn1485, Asn1534, Asn1809, Asn1184, Asn1210, Asn1261, Asn1275, Asn1301, Asn1366, Asn1392, and Asn2162 ( NX_P24821 [NX_P24821-1] )
Modification sites at PhosphoSitePlus ( P24821 )
Glycosylation from GlyConnect TENA_HUMAN (1792)
Glycosylation from GlyGen (P24821) 32 sites, 203 N-linked glycans (15 sites), 2 O-linked glycans (8 sites)
- Protein Refseq
- XP_005252029.1; XP_005252030.1; XP_005252031.1; XP_005252032.1; XP_006717159.1
- Function
- Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration.
Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes.
Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6.
In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells.
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone F16-131I"
- CAT
- Product Name
See other products for "Tnc"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-877 | Anti-Human Tenascin C/TNC Recombinant Antibody (Tenatumomab) | IHC | IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-587CT-F(E) | Human Anti-TNC Recombinant Antibody; Fab Fragment (TAB-587CT-F(E)) | ELISA, FC | Human Fab |
| TAB-588CT-F(E) | Human Anti-TNC Recombinant Antibody; Fab Fragment (TAB-588CT-F(E)) | ELISA, FC | Human Fab |
| TAB-589CT-F(E) | Human Anti-TNC Recombinant Antibody; Fab Fragment (TAB-589CT-F(E)) | ELISA, FC | Human Fab |
| TAB-590CT-F(E) | Human Anti-TNC Recombinant Antibody; Fab Fragment (TAB-590CT-F(E)) | ELISA, FC | Human Fab |
| TAB-591CT-F(E) | Anti-Human Tenascin C Recombinant Antibody Fab Fragment (2B10) | ELISA, IF | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0810MZ | Chicken Anti-Tenascin C Polyclonal IgY | WB | Chicken antibody |
| BRD-0910MZ | Chicken Anti-Tenascin C Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2050CQ | Rat Anti-TNC Recombinant Antibody (clone CBL402) | WB, ICC, Neut | Rat IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3601 | Rabbit Anti-TNC Recombinant Antibody (clone DS3601AB) | WB, IHC, ICC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC2108 | PE-B*07:02/Human TNC (IATVDSYVI) MHC Tetramer | FCM | |
| MHC-LC2109 | APC-B*07:02/Human TNC (IATVDSYVI) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0441-YC | Mouse Anti-TNC Recombinant Antibody (clone ST2146) | ELISA, WB, FC, FuncS | Mouse IgG2b, κ |
| HPAB-0443-YC | Human Anti-TNC Recombinant Antibody (HPAB-0443-YC) | ELISA, IHC | Human IgG |
| HPAB-0444-YC | Human Anti-TNC Recombinant Antibody (HPAB-0444-YC) | ELISA, IHC | Human IgG |
| HPAB-0445-YC | Human Anti-TNC Recombinant Antibody (HPAB-0445-YC) | ELISA, IHC | Human IgG |
| HPAB-M0678-YC | Mouse Anti-TNC Recombinant Antibody (HPAB-M0678-YC) | ELISA, SPR, IHC | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0441-YC-F(E) | Mouse Anti-TNC Recombinant Antibody (clone ST2146); Fab Fragment | ELISA, WB, FC | Mouse Fab |
| HPAB-0320CQ-F(E) | Mouse Anti-TNC Recombinant Antibody; Fab Fragment (HPAB-0320CQ-F(E)) | ELISA, WB | Mouse Fab |
| HPAB-M0678-YC-F(E) | Mouse Anti-TNC Recombinant Antibody; Fab Fragment (HPAB-M0678-YC-F(E)) | ELISA | Mouse Fab |
| HPAB-0190-WJ-F(E) | Human Anti-TNC Recombinant Antibody; Fab Fragment (HPAB-0190-WJ-F(E)) | ELISA | Human Fab |
| HPAB-1918-FY-S(P) | Mouse Anti-TNC Recombinant Antibody (clone 81C6); Fab Fragment | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-877 | Afuco™ Anti-TNC ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-877) | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0190-WJ-S(P) | Human Anti-TNC Recombinant Antibody; scFv Fragment (HPAB-0190-WJ-S(P)) | ELISA | Human scFv |
| HPAB-AP203-YC-S(P) | Mouse Anti-TNC Recombinant Antibody; scFv Fragment (HPAB-AP203-YC-S(P)) | ELISA, FuncS | Mouse scFv |
| HPAB-AP204-YC-S(P) | Mouse Anti-TNC Recombinant Antibody; scFv Fragment (HPAB-AP204-YC-S(P)) | ELISA, FuncS | Mouse scFv |
| HPAB-N0264-YC-S(P) | Human Anti-TNC Recombinant Antibody; scFv Fragment (HPAB-N0264-YC-S(P)) | ELISA, FuncS | Human scFv |
| HPAB-N0265-YC-S(P) | Human Anti-TNC Recombinant Antibody; scFv Fragment (HPAB-N0265-YC-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NBD-0083-YJ-VHH | Camelid Anti-TNC Recombinant Single Domain Antibody (NBD-0083-YJ-VHH) | ELISA, IF | Camelid VHH |
| NBD-0084-YJ-VHH | Camelid Anti-TNC Recombinant Single Domain Antibody (NBD-0084-YJ-VHH) | ELISA, IF, In vivo imaging | Camelid VHH |
| NBD-0085-YJ-VHH | Camelid Anti-TNC Recombinant Single Domain Antibody (NBD-0085-YJ-VHH) | ELISA, IF, In vivo imaging | Camelid VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY187 | Human Anti-TNC (clone F16-131I) scFv-Fc Chimera | IHC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2312 | Anti-TNC Immunohistochemistry Kit | IHC | |
| VS-0525-XY7346 | Anti-Human TNC Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-YC313 | Recombinant Anti-TNC Eliminating Antibody, pH-Sensitive (ST2146 var.) | Antigen-Sweeping In Vivo. | Mouse IgG2b kappa |
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