Anti-Human Tenascin C/TNC Recombinant Antibody (Tenatumomab)
CAT#: TAB-877
Recombinant humanized (from mouse) antibody expressed in CHO binding to human Tenascin C/TNC. Tenatumomab is a monoclonal antibody designed for the treatment of cancer.
Published Data
Gene Expression
IHC
Figure 1 Tenascin-C expression was evaluated with tenatumomab antibody.
Cases were graded according to scoring intensity as strong.
Gritti, G., Gianatti, A., Petronzelli, F., De Santis, R., Pavoni, C., Rossi, R. L., ... & Barbui, A. M. (2018). Evaluation of tenascin-C by tenatumomab in T-cell non-Hodgkin lymphomas identifies a new target for radioimmunotherapy. Oncotarget, 9(11), 9766.
IHC
Figure 2 Tenascin-C expression in the different T-cell NHL subtypes.
ALCL: anaplastic large cell lymphoma; ALK: anaplastic large cell lymphoma kinase.
Gritti, G., Gianatti, A., Petronzelli, F., De Santis, R., Pavoni, C., Rossi, R. L., ... & Barbui, A. M. (2018). Evaluation of tenascin-C by tenatumomab in T-cell non-Hodgkin lymphomas identifies a new target for radioimmunotherapy. Oncotarget, 9(11), 9766.
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Normal Tissue
Figure 1 Cerebral cortex
Neuropil
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4592/12212_B_7_5.jpg
Normal Tissue
Figure 2 Kidney
Cells in glomeruli
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4823/13810_A_8_5.jpg
Normal Tissue
Figure 3 Testis
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4592/12212_A_5_6.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced.
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000041982-TNC
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Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Mouse
- Derivation
- Mouse
- Type
- IgG2b
- Species Reactivity
- Human
- Applications
- IHC
- Generic Name
- Tenatumomab
- UNII
- 7C201CLB71
- Related Disease
- Cancers
Product Property
- Purity
- >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
- Storage
- Store it under sterile conditions at -20°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage.
Applications
- Application Notes
- The Human Tenascin C/TNC antibody has been reported in applications of Immunohistochemistry.
Target
- Alternative Names
- Tenatumomab;ST2146;TNC;tenascin C;hexabrachion (tenascin C, cytotactin) , HXB;tenascin;hexabrachion (tenascin);MGC167029;TN;GP 150-225;cytotactin;neuronectin;myotendinous antigen;tenascin-C isoform 14/AD1/16;glioma-associated-extracellular matrix antigen;
- Gene ID
- 3371
- UniProt ID
- P24821
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Biosimilar Overview
Please refer to Tenatumomab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Tenatumomab.
Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
See other products for "Tenatumomab"
Afuco™ Anti-TNC ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-877)This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant humanized (from mouse) antibody expressed in CHO binding to human Tenascin C/TNC. It is a monoclonal antibody designed for the treatment of cancer.
See other products for "Tnc"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1379z | Mouse Anti-TNC Recombinant Antibody (clone 22B10) | WB, IP, IF, IHC, ELISA | Mouse IgG1 |
| HPAB-0441-YC | Mouse Anti-TNC Recombinant Antibody (clone ST2146) | ELISA, WB, FC, FuncS | Mouse IgG2b, κ |
| HPAB-0443-YC | Human Anti-TNC Recombinant Antibody (HPAB-0443-YC) | ELISA, IHC | Human IgG |
| HPAB-0444-YC | Human Anti-TNC Recombinant Antibody (HPAB-0444-YC) | ELISA, IHC | Human IgG |
| HPAB-0445-YC | Human Anti-TNC Recombinant Antibody (HPAB-0445-YC) | ELISA, IHC | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-587CT-S(P) | Human Anti-TNC Recombinant Antibody; scFv Fragment (TAB-587CT-S(P)) | ELISA, FC | Human scFv |
| TAB-588CT-S(P) | Human Anti-TNC Recombinant Antibody; scFv Fragment (TAB-588CT-S(P)) | ELISA, FC | Human scFv |
| TAB-589CT-S(P) | Human Anti-TNC Recombinant Antibody; scFv Fragment (TAB-589CT-S(P)) | ELISA, FC | Human scFv |
| TAB-590CT-S(P) | Human Anti-TNC Recombinant Antibody; scFv Fragment (TAB-590CT-S(P)) | ELISA, FC | Human scFv |
| TAB-591CT-S(P) | Anti-Human Tenascin C Recombinant Antibody scFv Fragment (2B10) | ELISA, IF | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0810MZ | Chicken Anti-Tenascin C Polyclonal IgY | WB | Chicken antibody |
| BRD-0910MZ | Chicken Anti-Tenascin C Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2050CQ | Rat Anti-TNC Recombinant Antibody (clone CBL402) | WB, ICC, Neut | Rat IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3601 | Rabbit Anti-TNC Recombinant Antibody (clone DS3601AB) | WB, IHC, ICC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC2108 | PE-B*07:02/Human TNC (IATVDSYVI) MHC Tetramer | FCM | |
| MHC-LC2109 | APC-B*07:02/Human TNC (IATVDSYVI) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0441-YC-S(P) | Mouse Anti-TNC Recombinant Antibody (clone ST2146); scFv Fragment | ELISA, WB, FC | Mouse scFv |
| HPAB-0443-YC-S(P) | Human Anti-TNC Recombinant Antibody; scFv Fragment (HPAB-0443-YC-S(P)) | ELISA, IHC | Human scFv |
| HPAB-0444-YC-S(P) | Human Anti-TNC Recombinant Antibody; scFv Fragment (HPAB-0444-YC-S(P)) | ELISA, IHC | Human scFv |
| HPAB-0445-YC-S(P) | Human Anti-TNC Recombinant Antibody; scFv Fragment (HPAB-0445-YC-S(P)) | ELISA, IHC | Human scFv |
| HPAB-1918-FY-F(E) | Mouse Anti-TNC Recombinant Antibody (clone 81C6); scFv Fragment | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0441-YC-F(E) | Mouse Anti-TNC Recombinant Antibody (clone ST2146); Fab Fragment | ELISA, WB, FC | Mouse Fab |
| HPAB-0443-YC-F(E) | Human Anti-TNC Recombinant Antibody; Fab Fragment (HPAB-0443-YC-F(E)) | ELISA, IHC | Human Fab |
| HPAB-0444-YC-F(E) | Human Anti-TNC Recombinant Antibody; Fab Fragment (HPAB-0444-YC-F(E)) | ELISA, IHC | Human Fab |
| HPAB-0445-YC-F(E) | Human Anti-TNC Recombinant Antibody; Fab Fragment (HPAB-0445-YC-F(E)) | ELISA, IHC | Human Fab |
| HPAB-0320CQ-F(E) | Mouse Anti-TNC Recombinant Antibody; Fab Fragment (HPAB-0320CQ-F(E)) | ELISA, WB | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-877 | Afuco™ Anti-TNC ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-877) | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NBD-0083-YJ-VHH | Camelid Anti-TNC Recombinant Single Domain Antibody (NBD-0083-YJ-VHH) | ELISA, IF | Camelid VHH |
| NBD-0084-YJ-VHH | Camelid Anti-TNC Recombinant Single Domain Antibody (NBD-0084-YJ-VHH) | ELISA, IF, In vivo imaging | Camelid VHH |
| NBD-0085-YJ-VHH | Camelid Anti-TNC Recombinant Single Domain Antibody (NBD-0085-YJ-VHH) | ELISA, IF, In vivo imaging | Camelid VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY187 | Human Anti-TNC (clone F16-131I) scFv-Fc Chimera | IHC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2312 | Anti-TNC Immunohistochemistry Kit | IHC | |
| VS-0525-XY7346 | Anti-Human TNC Immunohistochemistry Kit | IHC |
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