Human Anti-TNC (clone F16-131I) scFv-Fc Chimera
CAT#: VS-0425-FY187
The anti-TNC scFv-FC is a monoclonal antibody designed to target the Tenascin-C (TNC) protein. Tenascin-C is an extracellular matrix glycoprotein involved in cell adhesion, migration, and tissue remodeling. The scFv-FC format combines a single-chain variable fragment (scFv) that specifically binds to TNC with the human Fc domain, enhancing its stability, half-life, and potential for therapeutic applications. This antibody can be used for research, diagnostic, and therapeutic purposes, particularly in the fields of oncology, neurology, and regenerative medicine.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Neuropil
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4592/12212_B_7_5.jpg
Normal Tissue
Figure 2 Kidney
Cells in glomeruli
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4823/13810_A_8_5.jpg
Normal Tissue
Figure 3 Testis
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4592/12212_A_5_6.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced.
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000041982-TNC
❮
❯
Specifications
- Immunogen
- The immunogen is human tumor cells expressing CD44v6.
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human TNC
- Species Reactivity
- Human
- Clone
- F16-131I
- Applications
- Immunohistochemistry
- Related Disease
- Brain tumors
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Tenascin C; Glioma-Associated-Extracellular Matrix Antigen; Deafness, Autosomal Dominant 56; Hexabrachion (Tenascin); Myotendinous Antigen; Neuronectin; GP 150-225; Cytotactin; GMEM; TN-C; HXB; TN
- Gene ID
- 3371
- UniProt ID
- P24821
- Long Name
- Tenascin C
- Sequence Similarities
- Belongs to the tenascin family.
- Cellular Localization
- Secreted, extracellular space, extracellular matrix
- Post Translation Modifications
- Glycosylation at Asn38, Asn166, Asn184, Asn327, Asn788, Asn1018, Asn1034, Asn1079, Asn1445, Asn1455, Asn1093, Asn1119, Asn1485, Asn1534, Asn1809, Asn1184, Asn1210, Asn1261, Asn1275, Asn1301, Asn1366, Asn1392, and Asn2162
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect TENA_HUMAN (1792)
Glycosylation from GlyGen 32 sites, 203 N-linked glycans (15 sites), 2 O-linked glycans (8 sites)
- Protein Refseq
- XP_005252029.1; XP_005252030.1; XP_005252031.1; XP_005252032.1; XP_006717159.1
- Function
- Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration.
Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes.
Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6.
In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells.
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for VS-0425-FY187. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
See other products for "Clone F16-131I"
- CAT
- Product Name
See other products for "Tnc"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-877 | Anti-Human Tenascin C/TNC Recombinant Antibody (Tenatumomab) | IHC | IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-587CT | Human Anti-TNC Recombinant Antibody (TAB-587CT) | ELISA, FC | Human IgG4 |
| TAB-588CT | Human Anti-TNC Recombinant Antibody (TAB-588CT) | ELISA, FC | Human IgG4 |
| TAB-589CT | Human Anti-TNC Recombinant Antibody (TAB-589CT) | ELISA, FC | Human IgG4 |
| TAB-590CT | Human Anti-TNC Recombinant Antibody (TAB-590CT) | ELISA, FC | Human IgG4 |
| TAB-591CT | Anti-Human Tenascin C Recombinant Antibody (2B10) | ELISA, IF | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2007CT | Recombinant Mouse anti-Human TNC Monoclonal antibody (C764N) | IHC-Fr, IHC-P | |
| HPAB-0320CQ | Mouse Anti-TNC Recombinant Antibody (HPAB-0320CQ) | ELISA, WB, FuncS | Mouse IgG1, κ |
| HPAB-AP203-YC | Mouse Anti-TNC Recombinant Antibody (HPAB-AP203-YC) | ELISA, FuncS | Mouse IgG |
| HPAB-AP204-YC | Mouse Anti-TNC Recombinant Antibody (HPAB-AP204-YC) | IHC, ELISA, FuncS | Mouse IgG |
| VS3-CJ809 | Rabbit Anti-TNC Recombinant Antibody (VS3-CJ809) | WB, IHC, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0810MZ | Chicken Anti-Tenascin C Polyclonal IgY | WB | Chicken antibody |
| BRD-0910MZ | Chicken Anti-Tenascin C Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2050CQ | Rat Anti-TNC Recombinant Antibody (clone CBL402) | WB, ICC, Neut | Rat IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3601 | Rabbit Anti-TNC Recombinant Antibody (clone DS3601AB) | WB, IHC, ICC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC2108 | PE-B*07:02/Human TNC (IATVDSYVI) MHC Tetramer | FCM | |
| MHC-LC2109 | APC-B*07:02/Human TNC (IATVDSYVI) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0320CQ-F(E) | Mouse Anti-TNC Recombinant Antibody; Fab Fragment (HPAB-0320CQ-F(E)) | ELISA, WB | Mouse Fab |
| HPAB-AP203-YC-F(E) | Mouse Anti-TNC Recombinant Antibody; Fab Fragment (HPAB-AP203-YC-F(E)) | ELISA, FuncS | Mouse Fab |
| HPAB-AP204-YC-F(E) | Mouse Anti-TNC Recombinant Antibody; Fab Fragment (HPAB-AP204-YC-F(E)) | ELISA, FuncS | Mouse Fab |
| HPAB-N0264-YC-F(E) | Human Anti-TNC Recombinant Antibody; Fab Fragment (HPAB-N0264-YC-F(E)) | ELISA, FuncS | Human Fab |
| HPAB-N0265-YC-F(E) | Human Anti-TNC Recombinant Antibody; Fab Fragment (HPAB-N0265-YC-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-877 | Afuco™ Anti-TNC ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-877) | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0190-WJ-S(P) | Human Anti-TNC Recombinant Antibody; scFv Fragment (HPAB-0190-WJ-S(P)) | ELISA | Human scFv |
| HPAB-AP203-YC-S(P) | Mouse Anti-TNC Recombinant Antibody; scFv Fragment (HPAB-AP203-YC-S(P)) | ELISA, FuncS | Mouse scFv |
| HPAB-AP204-YC-S(P) | Mouse Anti-TNC Recombinant Antibody; scFv Fragment (HPAB-AP204-YC-S(P)) | ELISA, FuncS | Mouse scFv |
| HPAB-N0264-YC-S(P) | Human Anti-TNC Recombinant Antibody; scFv Fragment (HPAB-N0264-YC-S(P)) | ELISA, FuncS | Human scFv |
| HPAB-N0265-YC-S(P) | Human Anti-TNC Recombinant Antibody; scFv Fragment (HPAB-N0265-YC-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NBD-0083-YJ-VHH | Camelid Anti-TNC Recombinant Single Domain Antibody (NBD-0083-YJ-VHH) | ELISA, IF | Camelid VHH |
| NBD-0084-YJ-VHH | Camelid Anti-TNC Recombinant Single Domain Antibody (NBD-0084-YJ-VHH) | ELISA, IF, In vivo imaging | Camelid VHH |
| NBD-0085-YJ-VHH | Camelid Anti-TNC Recombinant Single Domain Antibody (NBD-0085-YJ-VHH) | ELISA, IF, In vivo imaging | Camelid VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2312 | Anti-TNC Immunohistochemistry Kit | IHC | |
| VS-0525-XY7346 | Anti-Human TNC Immunohistochemistry Kit | IHC |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
Application: FuncS, IF, Neut, ELISA, FC, IP, WB
Application: FuncS, IF, Neut, ELISA, FC, IP, ICC
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
-YJ5.png)
Application: WB, ELISA, FC, IHC, IP
Application: WB, ELISA, IF, FuncS, Apop, BA
Application: ELISA, IHC, FC, IP, IF, FuncS
Application: ELISA, IHC, FC, IP, IF, FuncS
Application: FC, IHC, Cyt, FuncS
Application: Neut, ELISA, IF, IP, FuncS, FC
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
