Human Anti-TNC (clone F16-131I) scFv-Fc Chimera (CAT#: VS-0425-FY187)
The anti-TNC scFv-FC is a monoclonal antibody designed to target the Tenascin-C (TNC) protein. Tenascin-C is an extracellular matrix glycoprotein involved in cell adhesion, migration, and tissue remodeling. The scFv-FC format combines a single-chain variable fragment (scFv) that specifically binds to TNC with the human Fc domain, enhancing its stability, half-life, and potential for therapeutic applications. This antibody can be used for research, diagnostic, and therapeutic purposes, particularly in the fields of oncology, neurology, and regenerative medicine.
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Normal Tissue
RNA Expression
Figure 1 Cerebral cortex
(Neuropil
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4592/12212_B_7_5.jpg
(Neuropil
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4592/12212_B_7_5.jpg
Figure 2 Kidney
(Cells in glomeruli
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4823/13810_A_8_5.jpg
(Cells in glomeruli
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4823/13810_A_8_5.jpg
Figure 3 Testis
(Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4592/12212_A_5_6.jpg
(Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4592/12212_A_5_6.jpg
Figure 4 RNA cell line category: Cell line enhanced.
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000041982-TNC
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000041982-TNC
Specifications
- Immunogen
- The immunogen is human tumor cells expressing CD44v6.
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human TNC
- Species Reactivity
- Human
- Clone
- F16-131I
- Applications
- Immunohistochemistry
- Related Disease
- Brain tumors
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Tenascin C; Glioma-Associated-Extracellular Matrix Antigen; Deafness, Autosomal Dominant 56; Hexabrachion (Tenascin); Myotendinous Antigen; Neuronectin; GP 150-225; Cytotactin; GMEM; TN-C; HXB; TN
- Gene ID
- 3371
- UniProt ID
- P24821
- Long Name
- Tenascin C
- Sequence Similarities
- Belongs to the tenascin family.
- Cellular Localization
- Secreted, extracellular space, extracellular matrix
- Post Translation Modifications
- Glycosylation at Asn38, Asn166, Asn184, Asn327, Asn788, Asn1018, Asn1034, Asn1079, Asn1445, Asn1455, Asn1093, Asn1119, Asn1485, Asn1534, Asn1809, Asn1184, Asn1210, Asn1261, Asn1275, Asn1301, Asn1366, Asn1392, and Asn2162
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect TENA_HUMAN (1792)
Glycosylation from GlyGen 32 sites, 203 N-linked glycans (15 sites), 2 O-linked glycans (8 sites)
- Protein Refseq
- XP_005252029.1; XP_005252030.1; XP_005252031.1; XP_005252032.1; XP_006717159.1
- Function
- Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration.
Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes.
Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6.
In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-877 | Anti-Human Tenascin C/TNC Recombinant Antibody (Tenatumomab) | IHC | IgG2b |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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