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TNFAIP3
This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene.
Protein class
Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Glandular and luminal cells, Basal keratinocytes, Suprabasal keratinocytes, T-cells, Endometrial ciliated cells, Macrophages)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (GAMG, Karpas-707, REH, U-266/84)
Interaction
Homodimer. Interacts with TNIP1, TAX1BP1 and TRAF2. Interacts with RNF11, ITCH and TAX1BP1 only after TNF stimulation; these interaction are transient and they are lost after 1 hour of stimulation with TNF (By similarity). Interacts with YWHAZ and YWHAH. Interacts with IKBKG; the interaction is induced by TNF stimulation and by polyubiquitin. Interacts with RIPK1. Interacts with UBE2N; the interaction requires TAX1BP1. Interacts with TRAF6; the interaction is inhibited by HTLV-1 protein Tax.
Molecular function
DNA-binding, Hydrolase, Multifunctional enzyme, Protease, Thiol protease, Transferase
More Types Infomation
Related Signaling Pathways
TNF Signaling Pathway
- Rabbit Anti-TNFAIP3 Polyclonal Antibody (MRO-2234-CN) (MRO-2234-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
-
- Species Reactivity: Human
- Application: FC, IHC-P, WB
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, FC, ICC, IF, IHC, IP
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: FC, ICC, IHC-P, WB
- Chicken Anti-TNFAIP3 Polyclonal IgY (BRD-0595MZ)
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- Species Reactivity: Human, Mouse
- Type: Chicken antibody
- Application: WB
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC-Fr, IHC-P, IF
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, ICC, IF, IHC, FC
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For Research Use Only. Not For Clinical Use.