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    TNFAIP3

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    For Research Use Only. Not For Clinical Use.


    Background

    This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene.
    Protein class

    Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets

    Predicted location

    Intracellular

    Single cell type specificity

    Cell type enhanced (Glandular and luminal cells, Basal keratinocytes, Suprabasal keratinocytes, T-cells, Endometrial ciliated cells, Macrophages)

    Immune cell specificity

    Low immune cell specificity

    Cell line specificity

    Cell line enhanced (GAMG, Karpas-707, REH, U-266/84)

    Interaction

    Homodimer. Interacts with TNIP1, TAX1BP1 and TRAF2. Interacts with RNF11, ITCH and TAX1BP1 only after TNF stimulation; these interaction are transient and they are lost after 1 hour of stimulation with TNF (By similarity). Interacts with YWHAZ and YWHAH. Interacts with IKBKG; the interaction is induced by TNF stimulation and by polyubiquitin. Interacts with RIPK1. Interacts with UBE2N; the interaction requires TAX1BP1. Interacts with TRAF6; the interaction is inhibited by HTLV-1 protein Tax.

    Molecular function

    DNA-binding, Hydrolase, Multifunctional enzyme, Protease, Thiol protease, Transferase

    More Types Infomation
    Related Signaling Pathways
    TNF Signaling Pathway TNF Signaling Pathway
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